Bionano Genomics Announces Release of Version 6.2 of its NxClinical Software with Significant New Capabilities for Cancer Research Applications Including HRD Analysis
Integrated HRD genomic scarring has been introduced into this latest version of NxClinical software, developed by BioDiscovery, to measure genomic instability in a platform-agnostic way. This analysis allows cancer researchers to gain important insights from genetic data they are already generating from widely available array and sequencing assays, including several from Illumina, ThermoFisher, and Agilent.
HRD represents a disruption to the normal cellular pathway that repairs double-stranded DNA breaks, which consequentially results in acquired chromosomal breakage. Clinical research has shown that cells with HRD are more sensitive to certain therapies, like Poly(ADP-Ribose) Polymerase (PARP) inhibitors and other DNA repair-targeting drugs; therefore, a measurement of HRD may be an effective pharmacogenetic biomarker across various tumor types.
NxClinical software includes measurement of three genomic scars – Loss of Heterozygosity (LOH), Telomeric Allelic Imbalance (TAI), and Large-Scale State Transitions (LST) – that signal large-scale genomic instability. The automation of genomic scar analysis can simplify and expand access to HRD status assessment of cancer samples and enhance the clarity and transparency of tumor profiles. This analysis has the potential to drive improved stratification for clinical trials and provide pharmacogenomic-driven decisions in a precise manner that is relevant to the underlying biology of the cancer under investigation.
Current tools for assessing HRD status are limited to targeted detection of point mutations in HR genes predicted to be causative of HRD or cannot detect abnormalities across the entire genome. NxClinical software can help resolve this limitation by providing a genome-wide scarring approach coupled with integrated SNV analysis of HR genes that may reveal critical insights to tumor biology. The proprietary analysis method assesses copy number and allelic changes across the genome to identify specific quantifiable signatures of HRD genomic instability.
Related to this new functionality, Bionano is participating as an industry partner with the nonprofit organization
“Scientific interest in tumor HRD status is high, given its potential to serve as a routine and effective biomarker for a wide range of cancer types,” stated
Forward-Looking Statements of
This press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. Words such as “can,” “could,” “potential,” “may,” “expect,” and similar expressions (as well as other words or expressions referencing future events, conditions or circumstances) convey uncertainty of future events or outcomes and are intended to identify these forward-looking statements. Forward-looking statements include statements regarding our intentions, beliefs, projections, outlook, analyses or current expectations concerning, among other things, the ability and utility of NxClinical 6.2 software to detect and identify HRD status, and resolve current limitations of tools for assessing HRD status; potential of HRD to serve as a routine and effective biomarker for a wide range of cancer types; ability of HRD analysis to unlock new insights and treatments for elevating human health; and expected enhancement of the performance of our HRD capabilities once we are able to integrate OGM data capabilities into NxClinical software. Each of these forward-looking statements involves risks and uncertainties. Actual results or developments may differ materially from those projected or implied in these forward-looking statements. Factors that may cause such a difference include the risks and uncertainties associated with: the impact of the COVID-19 pandemic on our business and the global economy; general market conditions; changes in the competitive landscape and the introduction of competitive technologies or improvements in existing technologies, including with respect to HRD analysis; changes in our strategic and commercial plans; our ability to obtain sufficient financing to fund our strategic plans and commercialization efforts; the ability of medical and research institutions to obtain funding to support adoption or continued use of our technologies; and the risks and uncertainties associated with our business and financial condition in general, including the risks and uncertainties described in our filings with the
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Source: Bionano Genomics