Bionano Announces Presentation of OGM Utility Across Key Applications at the American Society of Human Genetics (ASHG) Annual Meeting
- A sponsored session will feature Dr.
Brynn Levyfrom Columbia University Medical Center, Dr. Roger Stevenson, founder of Greenwood Genetic Center, and Dr. Alex Hastiefrom Bionano presenting on the utility of optical genome mapping (OGM) across constitutional genetics research applications
- An industry co-lab session led by Dr.
Sam Dougaparsadfrom Bionano will provide attendees with an overview of Bionano’s end-to-end OGM workflow, including details of the latest product developments and innovations to enhance, streamline and enable scalability
- Three additional scientific presentations will highlight the use of OGM in neurodevelopmental and prenatal research applications
- Twelve scientific posters will illustrate the application of OGM in research areas including hematological malignancies, genetic disorders, and cell manufacturing and bioprocessing quality control
ASHG’s annual meeting brings together industry, medical, and academic professionals to discuss advances in clinical genomics and genetics research. The ASHG conference will be held
As part of a sponsored session, Dr. Brynn Levy of
As part of a hosted CoLab session, Bionano’s senior technical specialist, Dr.
Three separate scientific presentations highlighting the utility of OGM will be given. Dr. Christopher Grochowksi of Baylor College Medicine will present on the use of OGM in neurodevelopmental disorder research. Dr. Jesse Bengtsson of
In addition, 12 posters featuring results from OGM applications in cytogenetic research will be presented at the conference.
Scientific presentations and poster sessions from Bionano and collaborators include:
|PB3258||Optical genome mapping identified a KMT2C exonic deletion in a Kleefstra syndrome subject resulting from maternal mosaicism||Brassell B.|
|PB3162||Automated ultra-high molecular weight DNA isolation from various sources enables high-throughput optical genome mapping||Hoischen A.|
|PB3291||Update to the CLIA diagnostic procedure using optical genome mapping for the diagnosis of facioscapulohumeral dystrophy||Jang J.|
|PB4978||B-allele frequency-based approach to detecting absence of heterozygosity enables detection of low-level mosaic events using optical genome mapping||Raksi A.|
|PB3517||Use of long read sequencing and optical genome mapping to solve unsolved rare Mendelian diseases||Wohler E.|
|PB3383||Genome integrity assessment by optical genome mapping for cell manufacturing/bioprocessing applications||Pang A.|
|PB5129||Optical genome mapping for genome-wide structural variation analysis in hematologic malignancies: results of a prospective study and impact on diagnosis and management
|PB2088||Optical genome mapping for detection of chromosomal aberrations in prenatal diagnosis||Zhang Q.|
|PB3257||Optical genome mapping as a potential routine clinical diagnostic method||Barseghyan H.|
|PB3444||Novel optical genome mapping algorithm for detection of structural variants in hematological cancers||Muggli M.|
|PB2089||Optical genome mapping versus chromosomal microarray analysis and karyotyping in prenatal diagnosis||Ping H.|
|PB4989||Characterization of cytogenetically cryptic abnormalities in pediatric acute myeloid leukemia by optical genome mapping||Raca G.|
|Platform Presentation||Break-induced replication mediated by inverted repeats underlie formation of pathogenic inverted triplications||Grochowski C.||
Conv. Center/Room 207A/Level 2
|Platform Presentation||MECP2 copy number variants studied by multiple approaches reveal impact of genomic structure to disease variability||Bengtsson J.||
Conv. Center/Ballroom B/Level 3
|Sponsored Session||Revolutionizing Cytogenomics with Optical Genome Mapping: Clinical Research Advancements in Postnatal Conditions and Neural Tube Disorders
||Hastie A., Levy B., Stevenson R.||
|Invited Presentation||Optical Genome Mapping: A New Option for Prenatal Diagnosis||Levy B.||
|Industry Co-Lab Session||Optical Genome Mapping as a Comprehensive Workflow for Revealing Structural Variants
“We are thrilled to see the incredible variety of presentations and posters at ASHG, which demonstrate the utilization of OGM across genetic disorder research. The scientific presentations are indicative of the growth in OGM studies, with researchers presenting their largest data sets to date for studies using OGM in rare disease, pre-and postnatal and neural tube defect research. The scale of these studies underscores the significance of the robust conclusions made by the research teams. We are proud of the continued evolution and advancement of our workflow and see its impact on the findings that will be presented at the conference,” commented
More details on the conference can be found here.
Bionano is a provider of genome analysis solutions that can enable researchers and clinicians to reveal answers to challenging questions in biology and medicine. The Company’s mission is to transform the way the world sees the genome through OGM solutions, diagnostic services and software. The Company offers OGM solutions for applications across basic, translational and clinical research. Through its Lineagen, Inc. d/b/a Bionano Laboratories business, the Company also provides diagnostic testing for patients with clinical presentations consistent with autism spectrum disorder and other neurodevelopmental disabilities. The Company also offers an industry-leading, platform-agnostic software solution, which integrates next-generation sequencing and microarray data designed to provide analysis, visualization, interpretation and reporting of copy number variants, single-nucleotide variants and absence of heterozygosity across the genome in one consolidated view. The Company additionally offers nucleic acid extraction and purification solutions using proprietary isotachophoresis (ITP) technology. For more information, visit www.bionano.com, www.bionanolaboratories.com or www.purigenbio.com.
Unless specifically identified, Bionano’s OGM products are for research use only and not for use in diagnostic procedures.
Forward-Looking Statements of Bionano
This press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. Words such as “potential,” “will,” and similar expressions (as well as other words or expressions referencing future events, conditions or circumstances) convey uncertainty of future events or outcomes and are intended to identify these forward-looking statements. Forward-looking statements include statements regarding our intentions, beliefs, projections, outlook, analyses or current expectations concerning, among other things, OGM’s utility for applications in constitutional (including prenatal and postnatal applications) and hematologic genetic disorder research, OGM’s utility for cell manufacturing and bioprocessing quality control analysis, and the utility of OGM for research in the areas reported in the presentations given and the posters made available at ASHG’s 2023 annual meeting, and the growth and adoption of OGM for use in research applications or cell manufacturing and bioprocessing quality control analysis. Each of these forward-looking statements involves risks and uncertainties. Actual results or developments may differ materially from those projected or implied in these forward-looking statements. Factors that may cause such a difference include the risks and uncertainties associated with: global and macroeconomic events, such as the impact of the COVID-19 pandemic, the ongoing
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Source: Bionano Genomics