Bionano Announces Commercial Release of New Kits for its Ionic System featuring New Chemistry for Nucleic Acid Extraction from FFPE and Tumor Tissue
Most clinical samples used in oncology research are stored as FFPE tissues, which often contain degraded or fragmented nucleic acid. Conventional extraction methods are labor intensive and can further damage nucleic acid during the extraction and purification process. The Ionic Purification System uses isotachophoresis (ITP) to extract, purify and concentrate nucleic acid from biological samples without binding, washing, or stripping from fixed surfaces. Since nucleic acids remain in their native form when using the ITP workflow on the Ionic system, it can be an ideal solution for many sample types, including limited and low-quality solid tumor and homologous recombination deficiency (HRD) samples.
The Ionic® G2 chemistry includes four new kits for use with the Ionic Purification System, including G2 FFPE to DNA, G2 FFPE to RNA, G2 FFPE Complete and G2 Tissue to DNA. Ionic G2 kits enable ITP to provide up to a potential 4.5-fold increase in nucleic acid yield over the leading column-based system, with higher quality sample results and reduced sample processing time. ITP on the Ionic system is currently focused on nucleic acid purification for applications with next-generation sequencing (NGS). Bionano is developing ITP solutions for optical genome mapping (OGM) that are planned to be available in the future.
“Bionano acquired Purigen so we could develop an ITP workflow for ultra-high molecular weight (UHMW) DNA. We’re continuing to support applications of ITP on the Ionic system in other areas, especially for NGS, because we believe it provides us a bridge to the molecular pathology community independent of OGM,” said
More information on the Ionic system can be found here.
Bionano is a provider of genome analysis solutions that can enable researchers and clinicians to reveal answers to challenging questions in biology and medicine. The Company’s mission is to transform the way the world sees
the genome through OGM solutions, diagnostic services and software. The Company offers OGM solutions for applications across basic, translational and clinical research. Through its
Forward-Looking Statements of Bionano
This press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. Words such as “believe,” “can,” “potential” and similar expressions (as well as other words or expressions referencing future events, conditions or circumstances) convey uncertainty of future events or outcomes and are intended to identify these forward-looking statements. Forward-looking statements include statements regarding our intentions, beliefs, projections, outlook, analyses or current expectations concerning, among other things, the potential of the Ionic Purification System to offer improvements in quality and yield of nucleic acid extracted from complex biological samples including those with low cell counts or otherwise challenging sample types, such as FFPE tumor samples; the potential of the Ionic G2 kits to enable ITP to improve the quality and yield of nucleic acids when compared to column-based methods; and the potential of the Ionic Purification System and the Ionic G2 kits to be an ideal solution for many sample types, including limited and low-quality solid tumor and homologous recombination deficiency (HRD) samples. Each of these forward-looking statements involves risks and uncertainties. Actual results or developments may differ materially from those projected or implied in these forward-looking statements. Factors that may cause such a difference include the risks and uncertainties associated with: the impact of geopolitical and macroeconomic developments, such as recent and potential bank failures, the COVID-19 pandemic and the ongoing
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Source: Bionano Genomics