0001411690-23-000071 | 10-Q | XBRL Viewer

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Balance Sheet Account Details - Schedule of Components of Inventories (Details) - USD ($) $ in Thousands	Jun. 30, 2023	Dec. 31, 2022
Organization, Consolidation and Presentation of Financial Statements [Abstract]
Raw materials	$ 6,204	$ 5,319
Work in process	10,577	7,055
Finished goods	15,672	17,387
Inventory, net	$ 32,453	$ 29,761

Acquisitions

6 Months Ended

Jun. 30, 2023

Business Combination and Asset Acquisition [Abstract]

Acquisitions

Purigen Acquisition

In November 2022, the Company completed the acquisition of Purigen Biosystems, Inc. for approximately $32.0 million in cash and up to an aggregate of $32.0 million in cash payable based on the achievement of certain milestones. Cash of $1.2 million will be held in an escrow fund for purposes of satisfying any post-closing purchase price adjustments and indemnification claims under the Purigen Merger Agreement.

The purchase price allocation for the acquisition of Purigen is preliminary and subject to revision as additional information about the fair value of assets and liabilities becomes available. As permitted under ASC 805, the Company is allowed a measurement period, which may not exceed one year, in which to complete its accounting for the acquisition. Per the terms of the Purigen Merger Agreement, the purchase price is still subject to adjustment for the final determination of deferred and current tax assets and liabilities. During the second quarter of 2023, the Company recorded an increase in the estimated return of cash to buyer from escrow in the amount of $5,000, with the offset recorded to goodwill.

The following is the purchase price for the acquisition of Purigen:


Cash	$	32,034,000
Estimated fair value of milestone consideration	12,970,000
Return of cash to buyer from escrow	(95,000)
Total purchase price	$	44,909,000

The total purchase price was allocated to Purigen’s tangible and identifiable intangible assets acquired and liabilities assumed based on their estimated fair values as of the acquisition date, with the excess recorded as goodwill, as follows:


Cash & cash equivalents	$	290,000
Accounts receivable	259,000
Inventory	944,000
Prepaid expenses and other current assets	184,000
Property and equipment, net	805,000
Restricted cash	400,000
Operating lease right-of-use assets	1,636,000
Other long-term assets	533,000
Intangible assets	20,000,000
Goodwill	22,646,000
Accounts payable and other accrued liabilities	(1,152,000)
Operating lease liability (short-term and long-term)	(1,636,000)
Net assets acquired	$	44,909,000

The acquisition date fair values of identifiable intangible assets acquired are as following:


Developed technology	$	18,800,000
Customer relationships	200,000
Tradename	1,000,000
Fair value of identifiable intangible assets	$	20,000,000

The Company uses the income approach to derive the fair value of the identified intangible assets acquired. This approach calculates fair value by estimating future cash flows attributable to the assets and then discounting these cash flows to a present value using a risk-adjusted discount rate.

The customer relationships and trade name intangibles are being amortized on a straight-line basis over their estimated useful lives of 5 years. The developed technology intangible is being amortized on a straight-line basis over its estimated useful live of 15 years. Straight-line amortization was determined to be materially consistent with the pattern of expected use of the intangible assets.

As the Company began integrating Purigen’s operations with its existing operations during the fourth quarter of 2022, it is not practical or meaningful to distinguish Purigen’s expenses or net income or loss from that of the combined operations.

Pro forma Financial Information

The unaudited pro forma financial information in the table below summarizes the combined results of operations for the Company and Purigen as if the companies had been combined as of the beginning of the year prior to the acquisition. These amounts have been calculated after applying the Company’s accounting policies and adjusting the results of Purigen to reflect the additional amortization that would have been charged assuming the fair value adjustments to intangible assets had been applied at the beginning of the year prior to the acquisition. The following unaudited pro forma financial information is for informational purposes only and is not necessarily indicative of the results of operations that would have been achieved as if the acquisition had taken place as of January 1, 2021.


	Three Months Ended June 30		Six Months Ended June 30,
	2022		2022
Revenue	$	7,232,000	$	13,452,000
Net loss	(34,469,000)		(66,519,000)
Basic and diluted net loss per share	$	(1.21)	$	(2.33)

Condensed Consolidated Statements of Cash Flows (Unaudited) - USD ($) $ in Thousands	6 Months Ended
	Jun. 30, 2023	Jun. 30, 2022
Operating activities:
Net loss	$ (76,038)	$ (62,112)
Adjustments to reconcile net loss to net cash used by operating activities:
Depreciation and amortization expense	6,487	4,475
Amortization of financing lease right-of-use asset	102	117
Amortization (accretion) of interest on securities	(226)	551
Non-cash lease expense	20	337
Net realized loss (gain) on investments	23	0
Stock-based compensation	7,814	10,879
Change in fair value of contingent consideration	2,218	158
Cost of leased equipment sold to customer	88	204
Changes in operating assets and liabilities:
Accounts receivable	(590)	24
Inventory	(7,345)	(12,095)
Prepaid expenses and other current assets	1,785	277
Other assets	(587)	(91)
Accounts payable	(791)	(2,073)
Accrued expenses and contract liabilities	(2,069)	(1,477)
Net cash used in operating activities	(69,109)	(60,826)
Investing Activities:
Purigen acquisition, return of purchase consideration from escrow	96	694
Purchases of property and equipment	(839)	(371)
Purchase of available for sale securities	0	(29,541)
Sale and maturity of available for sale securities	46,879	93,475
Construction in progress	(32)	(1,080)
Sale of property and equipment	0	27
Net cash provided by investing activities	46,104	63,204
Financing activities:
Principal payments on financing lease liability	(22)	(17)
Proceeds from sale of common stock	33,487	0
Offering expenses on sale of common stock	(837)	0
Proceeds from sale of common stock under employee stock purchase plan	92	75
Proceeds from warrant and option exercises	23	152
Net cash provided by financing activities	32,743	210
Effect of exchange rates on cash, cash equivalents and restricted cash	27	0
Net decrease in cash, cash equivalents and restricted cash	9,765	2,588
Cash, cash equivalents and restricted cash at beginning of period	5,491	24,571
Cash, cash equivalents and restricted cash at end of period	15,256	27,159
Reconciliation of cash, cash equivalents and restricted cash reported within the unaudited condensed consolidated balance sheets to the total amounts reported on the unaudited condensed consolidated statements of cash flows
Cash and cash equivalents	14,856	27,159
Restricted cash	400	0
Total cash, cash equivalents and restricted cash at end of period	15,256	27,159
Supplemental cash flow disclosures:
Cash paid for interest	149	139
Cash paid for operating lease liabilities	1,291	695
Supplemental disclosure of non-cash investing and financing activities:
Transfer of instruments and servers from inventory to property and equipment, net	4,615	3,890
Property and equipment included in accounts payable	104	0
Construction in Progress Expenditures Incurred but Not yet Paid	65	0
Operating lease liabilities resulting from obtaining right-of-use assets	$ 0	$ 517

Acquisitions - Narrative (Details) - Purigen - USD ($) $ in Thousands	1 Months Ended	3 Months Ended
	Nov. 30, 2022	Jun. 30, 2023
Business Acquisition [Line Items]
Cash consideration transferred in acquisition	$ 32,034
Consideration milestone payment, maximum	32,000
Cash held in escrow fund	$ 1,200
Increase in estimated return of cash to buyer		$ 5
Tradename
Business Acquisition [Line Items]
Intangible assets useful life	5 years
Developed technology
Business Acquisition [Line Items]
Intangible assets useful life	15 years

Balance Sheet Account Details - Schedule of Intangible Assets (Details) - USD ($) $ in Thousands	Jun. 30, 2023	Dec. 31, 2022
Finite-Lived Intangible Assets [Line Items]
Gross Carrying Amount	$ 48,380	$ 48,380
Accumulated Amortization	(10,923)	(7,339)
Net Carrying Amount	37,457	41,041
Tradename
Finite-Lived Intangible Assets [Line Items]
Gross Carrying Amount	2,630	2,630
Accumulated Amortization	(815)	(552)
Net Carrying Amount	1,815	2,078
Customer relationships
Finite-Lived Intangible Assets [Line Items]
Gross Carrying Amount	4,150	4,150
Accumulated Amortization	(1,587)	(1,172)
Net Carrying Amount	2,563	2,978
Developed technology
Finite-Lived Intangible Assets [Line Items]
Gross Carrying Amount	41,600	41,600
Accumulated Amortization	(8,521)	(5,615)
Net Carrying Amount	$ 33,079	$ 35,985

Stockholders’ Equity and Stock-Based Compensation - Stock Option Activity (Details) $ / shares in Units, shares in Thousands, $ in Thousands	6 Months Ended	12 Months Ended
	Jun. 30, 2023 USD ($) $ / shares shares	Dec. 31, 2022 USD ($) $ / shares shares
Shares of Stock under Stock Options
Beginning balance (in shares) \| shares	2,402
Granted (in shares) \| shares	1,181
Exercised (in shares) \| shares	(4)
Canceled (in shares) \| shares	(233)
Ending balance (in shares) \| shares	3,346	2,402
Vested and exercisable (in shares) \| shares	1,108
Weighted- Average Exercise Price
Beginning balance (in dollars per share) \| $ / shares	$ 32.80
Granted (in dollars per share) \| $ / shares	14.10
Exercised (in dollars per share) \| $ / shares	5.50
Canceled (in dollars per share) \| $ / shares	28.20
Ending balance (in dollars per share) \| $ / shares	26.60	$ 32.80
Vested and exercisable (in dollars per share) \| $ / shares	$ 33.90
Weighted- Average Remaining Contractual Term
Outstanding (in years)	8 years 7 months 17 days	8 years 6 months
Vested and exercisable (in years)	7 years 8 months 4 days
Aggregate Intrinsic Value
Beginning balance \| $	$ 2,068
Exercised \| $	25
Ending balance \| $	148	$ 2,068
Vested and exercisable \| $	$ 131

Organization and Basis of Presentation (Policies)	6 Months Ended
Organization and Basis of Presentation (Policies)	Jun. 30, 2023
Organization, Consolidation and Presentation of Financial Statements [Abstract]
Basis of Presentation	Basis of PresentationThe accompanying financial information has been prepared by the Company pursuant to the rules and regulations of the Securities and Exchange Commission (the “SEC”) for interim reporting purposes. The condensed consolidated financial statements are unaudited. The unaudited condensed consolidated financial statements reflect, in the opinion of the Company’s management, all adjustments, consisting of only normal recurring adjustments, necessary for a fair presentation of financial position, results of operations, changes in equity, and comprehensive loss and cash flows for each period presented in accordance with United States generally accepted accounting principles (“U.S. GAAP”). All intercompany transactions and balances have been eliminated. The operating results presented in these unaudited interim condensed financial statements are not necessarily indicative of the results that may be expected for any future periods. These interim unaudited condensed consolidated financial statements should be read in conjunction with the audited consolidated financial statements and related notes thereto included in the Company’s Annual Report on Form 10-K for the year ended December 31, 2022.
Reclassifications	Reclassifications Certain amounts reported in prior years have been reclassified to conform with the presentation in the current year. These reclassifications had no effect on the reported results of operations.
Liquidity and Going Concern	Liquidity and Going Concern The Company has experienced recurring net losses from operations, negative cash flows from operating activities, and accumulated deficit since its inception and expects to continue to incur net losses into the foreseeable future. As of June 30, 2023, the Company had approximately $14.9 million in cash and cash equivalents, $62.2 million in short term investments, and working capital of $89.1 million. The Company has an accumulated deficit of $424.8 million as of June 30, 2023. During the six months ended June 30, 2023, the Company used $69.1 million cash in operations. Management expects operating losses and negative cash flows to continue for at least the next year as the Company continues to incur costs related to research and commercialization efforts. Management has prepared cash flows forecasts which indicate that based on the Company’s expected operating losses and negative cash flows, there is substantial doubt about the Company’s ability to continue as a going concern within twelve months after the date that the unaudited condensed consolidated financial statements for the three and six months ended June 30, 2023, are issued. Management’s ability to continue as a going concern is dependent upon its ability to raise additional funding. Management’s plans to raise additional capital to fulfill its operating and capital requirements for at least 12 months include public or private equity or debt financings. However, the Company may not be able to secure such financing in a timely manner or on favorable terms, if at all. Furthermore, if the Company issues equity securities to raise additional funds, its existing stockholders may experience dilution, and the new equity securities may have rights, preferences and privileges senior to those of the Company’s existing stockholders. The unaudited condensed consolidated financial statements have been prepared on a going concern basis, which contemplates the realization of assets and settlement of liabilities in the normal course of business, and do not include any adjustments to reflect the outcome of this uncertainty.
Goodwill	Goodwill Goodwill arises when the purchase price of an acquired business exceeds the fair value of the identifiable net assets acquired, with such excess recorded as goodwill on the balance sheet. Goodwill is not subsequently amortized. Goodwill is reviewed for impairment annually (during the fourth quarter) or more frequently if indications of impairment exist. Goodwill is assigned to specific reporting units for purposes of impairment assessment. The Company has determined that it has a single operating segment and a single reporting unit. In testing goodwill for impairment, the Company will first assess qualitative factors to determine whether it is more likely than not that the fair value of the reporting unit is less than its carrying amount. If the qualitative assessment indicates that it is more likely than not that the fair value of the reporting unit is less than its carrying value, then the Company will perform a quantitative impairment analysis by comparing the fair value of the reporting unit to the carrying value of the reporting unit, including goodwill. An impairment charge for goodwill is recognized for the amount by which the carrying value of the reporting unit exceeds its fair value, not to exceed the total goodwill allocated to the reporting unit. As of June 30, 2023, we performed a qualitative assessment of goodwill impairment which included an evaluation of changes in industry, market and macroeconomic conditions as well as consideration of our financial performance and any significant trends. Our qualitative assessment indicated that it was not more likely than not that goodwill is impaired as of June 30, 2023. If we experience a sustained decline in our stock price or other material changes in the significant assumptions that affect the determination of the fair value of the Company’s single reporting unit, it may result in a goodwill impairment charge in future periods, and such charge may be material.
Recently Adopted Accounting Pronouncements	Recently Adopted Accounting Pronouncements In February 2016, the Financial Accounting Standards Board (“FASB”) issued Accounting Standards Update (“ASU”) No. 2016-13, Financial Instruments - Credit Losses: Measurement of Credit Losses on Financial Instruments (ASU 2016-13), which amends the impairment model by requiring entities to use a forward looking approach based on expected losses to estimate credit losses on certain types of financial instruments, including trade receivables and available for sale debt securities. For trade receivables and other instruments, entities will be required to use a new forward-looking expected loss model that generally will result in the earlier recognition of allowances for losses. For available-for-sale debt securities with unrealized losses, the losses will be recognized as allowances rather than as reductions in the amortized cost of the securities. The Company adopted ASU 2016-13 as of January 1, 2023. The cumulative effect of applying the new credit loss standard was not material and, therefore, did not result in an adjustment to retained earnings. The adoption of this standard did not have a material impact on the Company’s consolidated financial statements or related financial statement disclosures. In accordance with ASU 2016-13, the Company no longer evaluates whether its available-for-sale debt securities in an unrealized loss position are other than temporarily impaired. Instead, the Company assesses whether such unrealized loss positions are credit-related. The credit-related portion of unrealized losses, and any subsequent improvements, are recorded in other income through an allowance account. Unrealized gains and losses that are not credit-related are included in accumulated other comprehensive income.

Acquisitions (Tables)

6 Months Ended

Jun. 30, 2023

Business Combination and Asset Acquisition [Abstract]

Schedule of Business Acquisitions

The following is the purchase price for the acquisition of Purigen:


Cash	$	32,034,000
Estimated fair value of milestone consideration	12,970,000
Return of cash to buyer from escrow	(95,000)
Total purchase price	$	44,909,000

Schedule of Recognized Identified Assets Acquired and Liabilities Assumed


Cash & cash equivalents	$	290,000
Accounts receivable	259,000
Inventory	944,000
Prepaid expenses and other current assets	184,000
Property and equipment, net	805,000
Restricted cash	400,000
Operating lease right-of-use assets	1,636,000
Other long-term assets	533,000
Intangible assets	20,000,000
Goodwill	22,646,000
Accounts payable and other accrued liabilities	(1,152,000)
Operating lease liability (short-term and long-term)	(1,636,000)
Net assets acquired	$	44,909,000

Schedule of Finite-Lived and Indefinite-Lived Intangible Assets Acquired as Part of Business Combination

The acquisition date fair values of identifiable intangible assets acquired are as following:


Developed technology	$	18,800,000
Customer relationships	200,000
Tradename	1,000,000
Fair value of identifiable intangible assets	$	20,000,000

Schedule of Business Acquisition, Pro Forma Information

The following unaudited pro forma financial information is for informational purposes only and is not necessarily indicative of the results of operations that would have been achieved as if the acquisition had taken place as of January 1, 2021.


	Three Months Ended June 30		Six Months Ended June 30,
	2022		2022
Revenue	$	7,232,000	$	13,452,000
Net loss	(34,469,000)		(66,519,000)
Basic and diluted net loss per share	$	(1.21)	$	(2.33)

Balance Sheet Account Details

6 Months Ended

Jun. 30, 2023

Organization, Consolidation and Presentation of Financial Statements [Abstract]

Balance Sheet Account Details

Accounts Receivable and Allowance for Credit Losses


	June 30, 2023		December 31, 2022
Accounts receivable, net:
Accounts receivable, trade	$	7,875,000	$	7,315,000
Allowance for credit losses	(262,000)		(293,000)
	$	7,613,000	$	7,022,000

Changes to the allowance for credit losses during the six months ended June 30, 2023 were as follows:


	Allowance for Credit Losses
Balance as of January 1, 2023	$	(293,000)
Provision for expected credit loss	(5,000)
Write-offs and payments	36,000
Balance as of June 30, 2023	$	(262,000)

The Company’s adoption of ASU No. 2016-13, Financial Instruments - Credit Losses, included an assessment of our aged trade receivables balances and their underlying credit risk characteristics. Our evaluation of past events, current conditions, and reasonable and supportable forecasts about the future resulted in an expectation of immaterial credit losses.

Inventory

The components of inventories are as follows:


	June 30, 2023		December 31, 2022
Inventory:
Raw materials	$	6,204,000	$	5,319,000
Work in process	10,577,000		7,055,000
Finished goods	15,672,000		17,387,000
	$	32,453,000	$	29,761,000

Intangible Assets

Intangible assets that are subject to amortization consisted of the following for the periods presented:


	June 30, 2023						December 31, 2022
	Gross Carrying Amount		Accumulated Amortization		Net Carrying Amount		Gross Carrying Amount		Accumulated Amortization		Net Carrying Amount
Trade name	$	2,630,000	$	(815,000)	$	1,815,000	$	2,630,000	$	(552,000)	$	2,078,000
Customer relationships	4,150,000		(1,587,000)		2,563,000		4,150,000		(1,172,000)		2,978,000
Developed technology	41,600,000		(8,521,000)		33,079,000		41,600,000		(5,615,000)		35,985,000
Intangibles, net	$	48,380,000	$	(10,923,000)	$	37,457,000	$	48,380,000	$	(7,339,000)	$	41,041,000

Intangible assets not subject to amortization totaled $0.1 million at June 30, 2023 and December 31, 2022, and related to the Company’s domain name.

Accrued Expenses

Accrued expenses consist of the following:


	June 30, 2023		December 31, 2022
Compensation expenses	$	5,917,000	$	7,002,000
Customer deposits	17,000		17,000
Taxes payable	897,000		825,000
Insurance	125,000		613,000
Professional fees and royalties	153,000		210,000
Warranty liabilities	640,000		489,000
Accrued clinical study fees	150,000		250,000
Other	417,000		1,146,000
Total	$	8,316,000	$	10,552,000

Investments and Fair Value Measurements - Contingent Consideration Liability (Details) - Contingent consideration - USD ($) $ in Thousands	6 Months Ended
	Jun. 30, 2023	Jun. 30, 2022
Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation, Calculation [Roll Forward]
Beginning balance	$ 22,352	$ 9,066
Liability recorded as a result of current period acquisition	0	0
Change in estimated fair value, recorded in selling, general and administrative expenses	2,218	158
Cash payments	0	0
Ending balance	$ 24,570	$ 9,224

Acquisitions - Pro Forma Information (Details) - Purigen - USD ($) $ / shares in Units, $ in Thousands	3 Months Ended	6 Months Ended
	Jun. 30, 2022	Jun. 30, 2022
Business Acquisition [Line Items]
Revenue	$ 7,232	$ 13,452
Net loss	$ (34,469)	$ (66,519)
Basic net loss per share (in dollars per share)	$ (1.21)	$ (2.33)
Diluted net loss per share (in dollars per share)	$ (1.21)	$ (2.33)

Revenue Recognition

6 Months Ended

Jun. 30, 2023

Revenue from Contract with Customer [Abstract]

Revenue Recognition

evenue Recognition

Revenue by Source


	Three Months Ended June 30,				Six Months Ended June 30,
	2023		2022		2023		2022
Instruments	$	2,450,000	$	2,446,000	$	4,346,000	$	4,042,000
Consumables	2,953,000		1,467,000		5,188,000		2,987,000
Software	1,206,000		882,000		2,522,000		1,972,000
Total product revenue	6,609,000		4,795,000		12,056,000		9,001,000
Service and other	2,053,000		1,875,000		4,021,000		3,365,000
Total revenue	$	8,662,000	$	6,670,000	$	16,077,000	$	12,366,000

The Company has revised the classification of its revenue between the categories in the table above for the June 30, 2022 statement of operations. In the June 30, 2022 statement of operations, “software” was included in “service and other.”

Revenue by Geographic Location


	Three Months Ended June 30,								Six Months Ended June 30,
	2023				2022				2023				2022
	$		%		$		%		$		%		$		%
Americas	$	4,313,000	50	%	$	2,611,000	39	%	$	7,757,000	48	%	$	5,940,000	48	%
EMEA	2,748,000		32	%	2,609,000		39	%	5,740,000		36	%	4,348,000		35	%
Asia Pacific	1,601,000		18	%	1,450,000		22	%	2,580,000		16	%	2,078,000		17	%
Total	$	8,662,000	100	%	$	6,670,000	100	%	$	16,077,000	100	%	$	12,366,000	100	%

The table above provides revenue from contracts with customers by source and geographic region (based on the customer’s billing address) on a disaggregated basis. Americas consists of North America and South America. EMEA consists of Europe, the Middle East, and Africa. Asia Pacific includes China, Japan, South Korea, Singapore, India and Australia. During the three months ended September 30, 2022, the Company changed the presentation of its revenues from India to be included in the Asia Pacific geographic region. Prior to the three months ended September 30, 2022, the Company had presented revenues from India in the EMEA geographic region. The impact of this change on prior period disclosures is immaterial.

For the three months ended June 30, 2023 and 2022, the United States represented 39.1% and 37.4% of total revenue, respectively. For the six months ended June 30, 2023 and 2022, the United States represented 40.1% and 40.9% of total revenue, respectively. For the three and six months ended June 30, 2023, China represented 15.0% and 10.2% of total revenue, respectively. For the three and six months ended June 30, 2022, China represented 19.3% and 12.9% of total revenue, respectively. No other countries represented greater than 10% of revenue during the three and six months ended June 30, 2023 and 2022.

Remaining Performance Obligations

As of June 30, 2023, the estimated revenue expected to be recognized in the future related to performance obligations that are unsatisfied was approximately $1.2 million. These remaining performance obligations primarily relate to extended warranty and support and maintenance obligations. The Company expects to recognize approximately 61.7% of this amount as revenue during the remainder of 2023, 31.2% in 2024, and 7.1% in 2025 and thereafter. Warranty revenue is included in service and other revenue.

The Company recognized revenue of approximately $0.4 million and $0.2 million during the three months ended June 30, 2023 and 2022, respectively, which was included in the contract liability balance at the end of the previous year, and revenue of approximately $1.1 million and $0.5 million during the six months ended June 30, 2023 and 2022, respectively, which was included in the contract liability balance at the end of the previous year.

- Definition

The entire disclosure of revenue from contract with customer to transfer good or service and to transfer nonfinancial asset. Includes, but is not limited to, disaggregation of revenue, credit loss recognized from contract with customer, judgment and change in judgment related to contract with customer, and asset recognized from cost incurred to obtain or fulfill contract with customer. Excludes insurance and lease contracts.

+ References

Reference 1: http://www.xbrl.org/2003/role/disclosureRef
-Topic 606
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 9
-Publisher FASB
-URI https://asc.fasb.org//1943274/2147479806/606-10-50-9

Reference 2: http://www.xbrl.org/2003/role/disclosureRef
-Topic 606
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 10
-Publisher FASB
-URI https://asc.fasb.org//1943274/2147479806/606-10-50-10

Reference 3: http://www.xbrl.org/2003/role/disclosureRef
-Topic 606
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 15
-Publisher FASB
-URI https://asc.fasb.org//1943274/2147479806/606-10-50-15

Reference 4: http://www.xbrl.org/2003/role/disclosureRef
-Topic 606
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 12
-Subparagraph (a)
-Publisher FASB
-URI https://asc.fasb.org//1943274/2147479806/606-10-50-12

Reference 5: http://www.xbrl.org/2003/role/disclosureRef
-Topic 606
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 12
-Subparagraph (b)
-Publisher FASB
-URI https://asc.fasb.org//1943274/2147479806/606-10-50-12

Reference 6: http://www.xbrl.org/2003/role/disclosureRef
-Topic 606
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 12
-Subparagraph (c)
-Publisher FASB
-URI https://asc.fasb.org//1943274/2147479806/606-10-50-12

Reference 7: http://www.xbrl.org/2003/role/disclosureRef
-Topic 606
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 12
-Subparagraph (d)
-Publisher FASB
-URI https://asc.fasb.org//1943274/2147479806/606-10-50-12

Reference 8: http://www.xbrl.org/2003/role/disclosureRef
-Topic 606
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 12
-Subparagraph (e)
-Publisher FASB
-URI https://asc.fasb.org//1943274/2147479806/606-10-50-12

Reference 9: http://www.xbrl.org/2003/role/disclosureRef
-Topic 606
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 13
-Subparagraph (b)(2)
-Publisher FASB
-URI https://asc.fasb.org//1943274/2147479806/606-10-50-13

Reference 10: http://www.xbrl.org/2003/role/disclosureRef
-Name Accounting Standards Codification
-Topic 606
-Publisher FASB
-URI https://asc.fasb.org//606/tableOfContent

+ Details

Balance Sheet Account Details - Schedule of Accounts Receivable (Details) - USD ($) $ in Thousands	Jun. 30, 2023	Dec. 31, 2022
Organization, Consolidation and Presentation of Financial Statements [Abstract]
Accounts receivable, trade	$ 7,875	$ 7,315
Allowance for credit losses	(262)	(293)
Accounts receivable, net	$ 7,613	$ 7,022

Organization and Basis of Presentation	6 Months Ended
Organization and Basis of Presentation	Jun. 30, 2023
Organization, Consolidation and Presentation of Financial Statements [Abstract]
Organization and Basis of Presentation	Organization and Basis of Presentation Description of Business Bionano Genomics, Inc. (collectively, with its consolidated subsidiaries, the “Company”) is a provider of genome analysis solutions that can enable researchers and clinicians to reveal answers to challenging questions in biology and medicine. The Company offers optical genome mapping (“OGM”) solutions for applications across basic, translational and clinical research, and for other applications including bioprocessing. Through its Lineagen, Inc. (doing business as Bionano Laboratories, “Bionano Laboratories”) business, the Company also provides diagnostic testing for patients with clinical presentations consistent with autism spectrum disorder and other neurodevelopmental disabilities. Through its BioDiscovery, LLC (“BioDiscovery”) business, the Company also offers platform-agnostic software solution, which integrates next-generation sequencing and microarray data designed to provide analysis, visualization, interpretation and reporting of copy number variants, single-nucleotide variants and absence of heterozygosity across the genome in one consolidated view. Through our Purigen Biosystems Inc. (“Purigen”) business, we offer nucleic acid extraction and purification solutions using proprietary isotachophoresis (“ITP”) technology. Reverse Stock Split On August 4, 2023, the Company filed a Certificate of Amendment to its Amended and Restated Certificate of Incorporation with the Secretary of State of the State of Delaware to effect a reverse stock split of all issued and outstanding shares of the Company’s common stock at a ratio of 1-for-10. The reverse stock split did not change the par value or the authorized number of shares of the Company’s common stock. The accompanying consolidated financial statements and notes to the consolidated financial statements present the retroactive effect of the reverse stock split on the Company’s common stock and per share amounts for all periods presented. Basis of Presentation The accompanying financial information has been prepared by the Company pursuant to the rules and regulations of the Securities and Exchange Commission (the “SEC”) for interim reporting purposes. The condensed consolidated financial statements are unaudited. The unaudited condensed consolidated financial statements reflect, in the opinion of the Company’s management, all adjustments, consisting of only normal recurring adjustments, necessary for a fair presentation of financial position, results of operations, changes in equity, and comprehensive loss and cash flows for each period presented in accordance with United States generally accepted accounting principles (“U.S. GAAP”). All intercompany transactions and balances have been eliminated. The operating results presented in these unaudited interim condensed financial statements are not necessarily indicative of the results that may be expected for any future periods. These interim unaudited condensed consolidated financial statements should be read in conjunction with the audited consolidated financial statements and related notes thereto included in the Company’s Annual Report on Form 10-K for the year ended December 31, 2022. Reclassifications Certain amounts reported in prior years have been reclassified to conform with the presentation in the current year. These reclassifications had no effect on the reported results of operations. Liquidity and Going Concern The Company has experienced recurring net losses from operations, negative cash flows from operating activities, and accumulated deficit since its inception and expects to continue to incur net losses into the foreseeable future. As of June 30, 2023, the Company had approximately $14.9 million in cash and cash equivalents, $62.2 million in short term investments, and working capital of $89.1 million. The Company has an accumulated deficit of $424.8 million as of June 30, 2023. During the six months ended June 30, 2023, the Company used $69.1 million cash in operations. Management expects operating losses and negative cash flows to continue for at least the next year as the Company continues to incur costs related to research and commercialization efforts. Management has prepared cash flows forecasts which indicate that based on the Company’s expected operating losses and negative cash flows, there is substantial doubt about the Company’s ability to continue as a going concern within twelve months after the date that the unaudited condensed consolidated financial statements for the three and six months ended June 30, 2023, are issued. Management’s ability to continue as a going concern is dependent upon its ability to raise additional funding. Management’s plans to raise additional capital to fulfill its operating and capital requirements for at least 12 months include public or private equity or debt financings. However, the Company may not be able to secure such financing in a timely manner or on favorable terms, if at all. Furthermore, if the Company issues equity securities to raise additional funds, its existing stockholders may experience dilution, and the new equity securities may have rights, preferences and privileges senior to those of the Company’s existing stockholders. The unaudited condensed consolidated financial statements have been prepared on a going concern basis, which contemplates the realization of assets and settlement of liabilities in the normal course of business, and do not include any adjustments to reflect the outcome of this uncertainty. Significant Accounting Policies During the three and six months ended June 30, 2023, there were no changes to the Company’s significant accounting policies as described in the Company’s Annual Report on Form 10-K for the year ended December 31, 2022. Goodwill Goodwill arises when the purchase price of an acquired business exceeds the fair value of the identifiable net assets acquired, with such excess recorded as goodwill on the balance sheet. Goodwill is not subsequently amortized. Goodwill is reviewed for impairment annually (during the fourth quarter) or more frequently if indications of impairment exist. Goodwill is assigned to specific reporting units for purposes of impairment assessment. The Company has determined that it has a single operating segment and a single reporting unit. In testing goodwill for impairment, the Company will first assess qualitative factors to determine whether it is more likely than not that the fair value of the reporting unit is less than its carrying amount. If the qualitative assessment indicates that it is more likely than not that the fair value of the reporting unit is less than its carrying value, then the Company will perform a quantitative impairment analysis by comparing the fair value of the reporting unit to the carrying value of the reporting unit, including goodwill. An impairment charge for goodwill is recognized for the amount by which the carrying value of the reporting unit exceeds its fair value, not to exceed the total goodwill allocated to the reporting unit. As of June 30, 2023, we performed a qualitative assessment of goodwill impairment which included an evaluation of changes in industry, market and macroeconomic conditions as well as consideration of our financial performance and any significant trends. Our qualitative assessment indicated that it was not more likely than not that goodwill is impaired as of June 30, 2023. If we experience a sustained decline in our stock price or other material changes in the significant assumptions that affect the determination of the fair value of the Company’s single reporting unit, it may result in a goodwill impairment charge in future periods, and such charge may be material. Recently Adopted Accounting Pronouncements In February 2016, the Financial Accounting Standards Board (“FASB”) issued Accounting Standards Update (“ASU”) No. 2016-13, Financial Instruments - Credit Losses: Measurement of Credit Losses on Financial Instruments (ASU 2016-13), which amends the impairment model by requiring entities to use a forward looking approach based on expected losses to estimate credit losses on certain types of financial instruments, including trade receivables and available for sale debt securities. For trade receivables and other instruments, entities will be required to use a new forward-looking expected loss model that generally will result in the earlier recognition of allowances for losses. For available-for-sale debt securities with unrealized losses, the losses will be recognized as allowances rather than as reductions in the amortized cost of the securities. The Company adopted ASU 2016-13 as of January 1, 2023. The cumulative effect of applying the new credit loss standard was not material and, therefore, did not result in an adjustment to retained earnings. The adoption of this standard did not have a material impact on the Company’s consolidated financial statements or related financial statement disclosures. In accordance with ASU 2016-13, the Company no longer evaluates whether its available-for-sale debt securities in an unrealized loss position are other than temporarily impaired. Instead, the Company assesses whether such unrealized loss positions are credit-related. The credit-related portion of unrealized losses, and any subsequent improvements, are recorded in other income through an allowance account. Unrealized gains and losses that are not credit-related are included in accumulated other comprehensive income.

Condensed Consolidated Statements of Stockholders’ Equity (Deficit) (Unaudited) - USD ($) $ in Thousands	Total	Common Stock	Additional Paid-in Capital	Accumulated Deficit	Accumulated Other Comprehensive Loss
Beginning balance (in shares) at Dec. 31, 2021		28,960,000
Beginning balance at Dec. 31, 2021	$ 337,118	$ 3	$ 553,773	$ (216,119)	$ (539)
Equity
Stock option exercises (in shares)		2,000
Stock option exercises	15		15
Stock-based compensation expense	5,102		5,102
Issuance of common stock due to the vesting of restricted stock units, net of shares withheld to cover taxes (in shares)		7,000
Net loss	(29,952)			(29,952)
Other comprehensive income (loss)	(1,098)				(1,098)
Ending balance (in shares) at Mar. 31, 2022		28,969,000
Ending balance at Mar. 31, 2022	311,185	$ 3	558,890	(246,071)	(1,637)
Beginning balance (in shares) at Dec. 31, 2021		28,960,000
Beginning balance at Dec. 31, 2021	337,118	$ 3	553,773	(216,119)	(539)
Equity
Net loss	(62,112)
Other comprehensive income (loss)	(1,379)
Ending balance (in shares) at Jun. 30, 2022		29,006,000
Ending balance at Jun. 30, 2022	284,734	$ 3	564,878	(278,229)	(1,918)
Beginning balance (in shares) at Mar. 31, 2022		28,969,000
Beginning balance at Mar. 31, 2022	311,185	$ 3	558,890	(246,071)	(1,637)
Equity
Stock option exercises (in shares)		25,000
Stock option exercises	136		136
Stock-based compensation expense	5,777		5,777
Issuance of common stock due to the vesting of restricted stock units, net of shares withheld to cover taxes (in shares)		(3,000)
Issue stock for employee stock purchase plan (in shares)		15,000
Issue stock for employee stock purchase plan	75		75
Net loss	(32,158)			(32,158)
Other comprehensive income (loss)	(281)				(281)
Ending balance (in shares) at Jun. 30, 2022		29,006,000
Ending balance at Jun. 30, 2022	$ 284,734	$ 3	564,878	(278,229)	(1,918)
Beginning balance (in shares) at Dec. 31, 2022	29,718,000	29,718,000
Beginning balance at Dec. 31, 2022	$ 249,398	$ 3	599,234	(348,715)	(1,124)
Equity
Stock option exercises (in shares)		4,000
Stock option exercises	23		23
Stock-based compensation expense	3,882		3,882
Issue common stock, net of issuance costs (in shares)		950,000
Issue common stock, net of issuance costs	14,848		14,848
Issuance of common stock due to the vesting of restricted stock units, net of shares withheld to cover taxes (in shares)		7,000
Net loss	(37,124)			(37,124)
Other comprehensive income (loss)	459				459
Ending balance (in shares) at Mar. 31, 2023		30,679,000
Ending balance at Mar. 31, 2023	$ 231,486	$ 3	617,987	(385,839)	(665)
Beginning balance (in shares) at Dec. 31, 2022	29,718,000	29,718,000
Beginning balance at Dec. 31, 2022	$ 249,398	$ 3	599,234	(348,715)	(1,124)
Equity
Stock option exercises (in shares)	4,000
Net loss	$ (76,038)
Other comprehensive income (loss)	$ 814
Ending balance (in shares) at Jun. 30, 2023	33,240,000	33,240,000
Ending balance at Jun. 30, 2023	$ 214,756	$ 3	639,814	(424,751)	(310)
Beginning balance (in shares) at Mar. 31, 2023		30,679,000
Beginning balance at Mar. 31, 2023	231,486	$ 3	617,987	(385,839)	(665)
Equity
Stock option exercises (in shares)		0
Stock option exercises	1		1
Stock-based compensation expense	3,932		3,932
Issue common stock, net of issuance costs (in shares)		2,552,000
Issue common stock, net of issuance costs	17,802		17,802
Issuance of common stock due to the vesting of restricted stock units, net of shares withheld to cover taxes (in shares)		(6,000)
Issue stock for employee stock purchase plan (in shares)		15,000
Issue stock for employee stock purchase plan	92		92
Net loss	(38,912)			(38,912)
Other comprehensive income (loss)	$ 355				355
Ending balance (in shares) at Jun. 30, 2023	33,240,000	33,240,000
Ending balance at Jun. 30, 2023	$ 214,756	$ 3	$ 639,814	$ (424,751)	$ (310)

Investments and Fair Value Measurements - Unrealized Losses Positions (Details) - USD ($) $ in Thousands	Jun. 30, 2023	Dec. 31, 2022
Fair Value
Less Than 12 Months, Fair Value	$ 25,631	$ 31,662
12 Months or Greater, Fair Value	36,575	74,452
Total	62,206	106,114
Gross Unrealized Loss
Less than 12 months, Gross Unrealized Loss	(67)	(116)
12 Months or Greater, Gross Unrealized Loss	(232)	(972)
Securities of government sponsored entities	(299)	(1,088)
Commercial paper
Fair Value
Less Than 12 Months, Fair Value	13,403	20,020
12 Months or Greater, Fair Value	0	0
Total	13,403	20,020
Gross Unrealized Loss
Less than 12 months, Gross Unrealized Loss	(16)	(73)
12 Months or Greater, Gross Unrealized Loss	0	0
Securities of government sponsored entities	(16)	(73)
Corporate notes/bonds
Fair Value
Less Than 12 Months, Fair Value	10,241	9,661
12 Months or Greater, Fair Value	36,575	74,452
Total	46,816	84,113
Gross Unrealized Loss
Less than 12 months, Gross Unrealized Loss	(39)	(27)
12 Months or Greater, Gross Unrealized Loss	(232)	(972)
Securities of government sponsored entities	(271)	(999)
Securities of government sponsored entities
Fair Value
Less Than 12 Months, Fair Value	1,987	1,981
12 Months or Greater, Fair Value	0	0
Total	1,987	1,981
Gross Unrealized Loss
Less than 12 months, Gross Unrealized Loss	(12)	(16)
12 Months or Greater, Gross Unrealized Loss	0	0
Securities of government sponsored entities	$ (12)	$ (16)

Revenue Recognition (Tables)

6 Months Ended

Jun. 30, 2023

Revenue from Contract with Customer [Abstract]

Schedule of Revenue Recognition

Revenue by Source


	Three Months Ended June 30,				Six Months Ended June 30,
	2023		2022		2023		2022
Instruments	$	2,450,000	$	2,446,000	$	4,346,000	$	4,042,000
Consumables	2,953,000		1,467,000		5,188,000		2,987,000
Software	1,206,000		882,000		2,522,000		1,972,000
Total product revenue	6,609,000		4,795,000		12,056,000		9,001,000
Service and other	2,053,000		1,875,000		4,021,000		3,365,000
Total revenue	$	8,662,000	$	6,670,000	$	16,077,000	$	12,366,000

Revenue by Geographic Location


	Three Months Ended June 30,								Six Months Ended June 30,
	2023				2022				2023				2022
	$		%		$		%		$		%		$		%
Americas	$	4,313,000	50	%	$	2,611,000	39	%	$	7,757,000	48	%	$	5,940,000	48	%
EMEA	2,748,000		32	%	2,609,000		39	%	5,740,000		36	%	4,348,000		35	%
Asia Pacific	1,601,000		18	%	1,450,000		22	%	2,580,000		16	%	2,078,000		17	%
Total	$	8,662,000	100	%	$	6,670,000	100	%	$	16,077,000	100	%	$	12,366,000	100	%

Stockholders’ Equity and Stock-Based Compensation - Restricted Stock and Performance Stock Activity (Details) shares in Thousands	6 Months Ended
	Jun. 30, 2023 $ / shares shares
RSUs
Stock Units
Beginning balance (in shares) \| shares	10
Granted (in shares) \| shares	247
Released (in shares) \| shares	(10)
Forfeited (in shares) \| shares	(17)
Ending balance (in shares) \| shares	230
Weighted- Average Grant Date Fair Value per Share
Beginning balance (in dollars per share) \| $ / shares	$ 47.40
Granted (in dollars per share) \| $ / shares	16.30
Released (in dollars per share) \| $ / shares	47.40
Forfeited (in dollars per share) \| $ / shares	16.30
Ending balance (in dollars per share) \| $ / shares	$ 16.30
PSUs
Stock Units
Beginning balance (in shares) \| shares	29
Granted (in shares) \| shares	0
Released (in shares) \| shares	0
Forfeited (in shares) \| shares	0
Ending balance (in shares) \| shares	29
Weighted- Average Grant Date Fair Value per Share
Beginning balance (in dollars per share) \| $ / shares	$ 47.4
Granted (in dollars per share) \| $ / shares	0
Released (in dollars per share) \| $ / shares	0
Forfeited (in dollars per share) \| $ / shares	0
Ending balance (in dollars per share) \| $ / shares	$ 47.4

Investments and Fair Value Measurements (Tables)

6 Months Ended

Jun. 30, 2023

Fair Value Disclosures [Abstract]

Schedule of Fair Value, Assets and Liabilities Measured on Recurring Basis

The following table presents the Company’s financial assets and liabilities measured at fair value on a recurring basis as of June 30, 2023 and December 31, 2022:


	June 30, 2023
	Total Fair Value and Carrying Value on Balance Sheet		Fair Value Measurement Category
			Level 1		Level 2		Level 3
Assets:
Commercial paper	$	13,403,000	$	—	$	13,403,000	$	—
Corporate notes/bonds	46,816,000				46,816,000		—
Securities of government sponsored entities	1,987,000		—		1,987,000		—
Total investments:	$	62,206,000	$	—	$	62,206,000	$	—
Money market funds	$	7,962,000	$	7,962,000	$	—	$	—
Liabilities:
Contingent consideration	$	24,570,000	$	—	$	—	$	24,570,000


	December 31, 2022
	Total Fair Value and Carrying Value on Balance Sheet		Fair Value Measurement Category
			Level 1		Level 2		Level 3
Assets:
Commercial paper	$	20,020,000	$	—	$	20,020,000	$	—
Corporate notes/bonds	86,094,000		—		86,094,000		—
Securities of government sponsored entities	1,981,000				1,981,000
Total investments:	$	108,095,000	$	—	$	108,095,000	$	—
Money market funds	$	1,868,000	$	1,868,000	$	—	$	—
Liabilities:
Contingent consideration	$	22,352,000	$	—	$	—	$	22,352,000

Schedule of Fair Value, Assets Measured on Recurring Basis, Unobservable Input Reconciliation

Changes in estimated fair value of contingent consideration liability in the six months ended June 30, 2023 is as follows:


	Contingent Consideration Liability (Level 3 Measurement)
Balance as of January 1, 2023	$	22,352,000
Liability recorded as a result of current period acquisition	—
Change in estimated fair value, recorded in selling, general and administrative expenses	2,218,000
Cash payments	—
Balance as of June 30, 2023	$	24,570,000

Changes in estimated fair value of contingent consideration liability in the six months ended June 30, 2022 is as follows:


	Contingent Consideration Liability (Level 3 Measurement)
Balance as of January 1, 2022	$	9,066,000
Liability recorded as a result of current period acquisition	—
Change in estimated fair value, recorded in selling, general and administrative expenses	158,000
Cash payments	—
Balance as of June 30, 2022	$	9,224,000

Schedule of Marketable Securities

As of June 30, 2023, the following table summarizes the amortized cost and the unrealized gains/losses of the available for sale securities:


	Remaining Contractual Maturity (in years)	Amortized Cost		Unrealized Gains		Unrealized Losses		Aggregate Estimated Fair Value
Commercial paper	Less than 1	$	13,420,000	$	—	$	(16,000)	$	13,404,000
Corporate notes/bonds	Less than 1	47,086,000		—		(271,000)		46,815,000
Securities of government sponsored entities	Less than 1	1,999,000		—		(12,000)		1,987,000
Total maturity less than 1 year		$	62,505,000	$	—	$	(299,000)	$	62,206,000
Corporate notes/bonds	1 to 5	—		—		—		—
Total		$	62,505,000	$	—	$	(299,000)	$	62,206,000

As of December 31, 2022, the following table summarizes the amortized cost and the unrealized gains/losses of the available for sale securities:


	Remaining Contractual Maturity (in years)	Amortized Cost		Unrealized Gains		Unrealized Losses		Aggregate Estimated Fair Value
Commercial paper	Less than 1	$	20,093,000	$	—	$	(73,000)	$	20,020,000
Corporate notes/bonds	Less than 1	72,823,000		1,000		(911,000)		71,913,000
Securities of government sponsored entities	Less than 1	1,998,000		—		(16,000)		1,982,000
Total maturity less than 1 year		$	94,914,000	$	1,000	$	(1,000,000)	$	93,915,000
Corporate notes/bonds	1 to 5	14,268,000		—		(88,000)		14,180,000
Total		$	109,182,000	$	1,000	$	(1,088,000)	$	108,095,000

As of June 30, 2023, the following table summarizes available-for-sale securities in an unrealized loss position with no credit losses reported:


	Less Than 12 Months				12 Months or Greater				Total
	Fair Value		Gross Unrealized Loss		Fair Value		Gross Unrealized Loss		Fair Value		Gross Unrealized Loss
Commercial paper	$	13,403,000	$	(16,000)	$	—	$	—	$	13,403,000	$	(16,000)
Corporate Notes/Bonds	10,241,000		(39,000)		36,575,000		(232,000)		46,816,000		(271,000)
Securities of Government Sponsored Entities	1,987,000		(12,000)		—		—		1,987,000		(12,000)
Total	$	25,631,000	$	(67,000)	$	36,575,000	$	(232,000)	$	62,206,000	$	(299,000)

As of December 31, 2022, the following table summarizes available-for-sale securities in an unrealized loss position with no credit losses reported:


	Less Than 12 Months				12 Months or Greater				Total
	Fair Value		Gross Unrealized Loss		Fair Value		Gross Unrealized Loss		Fair Value		Gross Unrealized Loss
Commercial paper	$	20,020,000	$	(73,000)	$	—	$	—	$	20,020,000	$	(73,000)
Corporate Notes/Bonds	9,661,000		(27,000)		74,452,000		(972,000)		84,113,000		(999,000)
Securities of Government Sponsored Entities	1,981,000		(16,000)		—		—		1,981,000		(16,000)
Total	$	31,662,000	$	(116,000)	$	74,452,000	$	(972,000)	$	106,114,000	$	(1,088,000)

Stockholders’ Equity and Stock-Based Compensation

6 Months Ended

Jun. 30, 2023

Share-Based Payment Arrangement [Abstract]

Stockholders’ Equity and Stock-Based Compensation

Reverse Stock Split

On August 4, 2023, the Company completed a reverse stock split of its outstanding shares of common stock pursuant to which every 10 shares of issued and outstanding common stock were exchanged for one share of common stock. No fractional shares were issued in the reverse stock split. Instead, the Company paid cash (without interest) equal to such fraction multiplied by $5.90 per share (a price equal to the average of the closing sales prices of the common stock on The Nasdaq Capital Market during regular trading hours for the five consecutive trading days immediately preceding August 4, with such average closing sales prices being adjusted to give effect to a Reverse Stock Split). All share and per share amounts included within these condensed consolidated financial statements have been retrospectively adjusted to reflect the reverse stock split.

Cowen At-the-Market Facility

On March 23, 2021, the Company entered into a Sales Agreement with Cowen and Company, LLC (“Cowen”) which provides for the sale, in the Company’s sole discretion, of shares of common stock having an aggregate offering price of up to $350.0 million through or to Cowen, acting as sales agent or principal, which was amended on March 9, 2023 to decrease the maximum aggregate offering price to $200.0 million for sales made on and after the date of the amendment (the “Cowen

ATM”). The Company agreed to pay Cowen a commission of up to 3.0% of the aggregate gross proceeds from each sale of shares, reimburse legal fees and disbursements and provide Cowen with customary indemnification and contribution rights. In August 2022, the Company sold approximately 0.7 million shares of common stock under the Cowen ATM at an average share price of $34.59 per share, and received gross proceeds of approximately $23.1 million before deducting offering costs of $0.6 million. During the six months ended June 30, 2023, the Company sold approximately 3.5 million shares of common stock under the Cowen ATM at an average share price of $9.56 per share, and received gross proceeds of approximately $33.5 million before deducting offering costs of $0.8 million. From July 1, 2023 through the date of the filing of this Quarterly Report on Form 10-Q, the Company has sold approximately 2.1 million shares of common stock under the Cowen ATM at an average share price of $6.16 per share, and received gross proceeds of approximately $13.0 million before deducting offering costs of $0.3 million.

Stock Warrants

A summary of the Company’s warrant activity during the six months ended June 30, 2023 was as follows:


	Shares of Stock under Warrants	Weighted- Average Exercise Price		Weighted- Average Remaining Contractual Term	Aggregate Intrinsic Value
Outstanding at January 1, 2023	436,000	$	59.60	0.76	$	273,000
Granted	—	—		—	—
Exercised	—	—		—	—
Canceled	—	—		—	—
Outstanding at June 30, 2023	436,000	$	59.60	0.27	$	—

Stock Options

A summary of the Company’s stock option activity during the six months ended June 30, 2023 was as follows:


	Shares of Stock under Stock Options	Weighted- Average Exercise Price		Weighted- Average Remaining Contractual Term	Aggregate Intrinsic Value
Outstanding at January 1, 2023	2,402,000	$	32.80	8.50	$	2,068,000
Granted	1,181,000	14.10		—
Exercised	(4,000)	5.50		—	25,000
Canceled	(233,000)	28.20		—
Outstanding at June 30, 2023	3,346,000	$	26.60	8.63	$	148,000
Vested and exercisable at June 30, 2023	1,108,000	$	33.90	7.68	$	131,000

For the three months ended June 30, 2023, the weighted-average grant date fair value of stock options granted was $5.36 per share. For the six months ended June 30, 2023, the weighted-average grant date fair value of stock options granted was $9.47 per share.

Stock-Based Compensation

The Company recognized stock-based compensation expense for the periods presented as follows:


	Three Months Ended June 30,				Six Months Ended June 30,
	2023		2022		2023		2022
Cost of product revenue	$	154,000	$	—	$	256,000	$	—
Cost of service and other revenue	44,000		—		88,000		$	—
Research and development	1,301,000		3,468,000		2,658,000		$	6,795,000
General and administrative	2,433,000		2,309,000		4,812,000		4,084,000
Total stock-based compensation expense	$	3,932,000	$	5,777,000	$	7,814,000	$	10,879,000

The weighted-average assumptions used in the Black-Scholes option pricing model to determine the fair value of the employee stock option grants during the periods presented were as follows:


	Three Months Ended June 30,				Six Months Ended June 30,
	2023		2022		2023		2022
Risk-free interest rate	3.9	%	2.8	%	3.9	%	2.1	%
Expected volatility	80.5	%	70.6	%	74.4	%	70.2	%
Expected term (in years)	5.5		5.7		5.9		6.0
Expected dividend yield	0.0	%	0.0	%	0.0	%	0.0	%

Restricted Stock

A restricted stock award in the amount of 0.5 million shares with a grant date fair value of $52.00 a share was granted as part of the acquisition of BioDiscovery. One-third of the Restricted Shares was scheduled to vest on October 18, 2022 and one-twelfth of the Restricted Shares was scheduled to vest every three months following October 18, 2022, subject to continuous service of the key employee. The fair value of the restricted stock award was based on the market value of common stock as of the date of grant and was amortized to stock-based compensation expense over the service period.

On October 4, 2022, the restricted stock award was modified due to the change in employment status of the key employee from full time to emeritus. As a result of the modification, the restricted stock award vested in full on October 4, 2022. The award was revalued on the modification date, resulting in a modified grant date fair value of $20.40 a share ($15.8 million less than the initial grant date fair value of the award). The fair value of the modified restricted stock award was based on the market value of common stock as of the modification date.

Restricted Stock Units and Performance Stock Units

The following table summarizes RSU activity during the six months ended June 30, 2023:


	Stock Units	Weighted- Average Grant Date Fair Value per Share
Outstanding at January 1, 2023	10,000	$	47.40
Granted	247,000	16.30
Released	(10,000)	47.40
Forfeited	(17,000)	16.30
Outstanding at June 30, 2023	230,000	$	16.30

The total intrinsic value of the RSUs that vested during the six months ended June 30, 2023 was $0.5 million, determined as of the date of vesting. The weighted average remaining contractual term for the RSUs is 3.6 years as of June 30, 2023.

The following table summarizes PSU activity during the six months ended June 30, 2023:


	Stock Units	Weighted- Average Grant Date Fair Value per Share
Outstanding at January 1, 2023	29,000	$	47.4
Granted	—	—
Released	—	—
Forfeited	—	—
Outstanding at June 30, 2023	29,000	$	47.4

The weighted average remaining contractual term for the PSUs is 0.5 years as of June 30, 2023.

Executive Option Grants and RSUs

On February 15, 2023, the compensation committee of the Company’s board of directors granted various executive officers stock options to purchase an aggregate of 0.3 million shares of common stock at an exercise price of $16.30 per share, and RSUs amounting to 0.1 million shares of common stock at a grant date fair value of $16.30 per share, in each case with an effective grant date and vesting commencement date of February 15, 2023 (the “Grant Date”). These stock option grants and RSUs were issued from the 2018 Plan. The shares subject to the option shall vest monthly over 48 months beginning on the one-month anniversary of the Grant Date, such that the option shall be fully vested and exercisable on the four-year anniversary of the Grant Date. The RSUs shall vest annually over four years beginning one year after the Grant Date, and the balance of the shares vest in a series of three successive equal annual installments measured from the first anniversary of the Grant Date, such that the RSU shall be fully vested on the four-year anniversary of the Grant Date.

Series A Preferred Stock

On April 13, 2023, the Company entered into an agreement with David Barker, the Chair of the Company’s board of directors, pursuant to which the Company agreed to issue and sell one share of the Company’s Series A Preferred Stock, par value $0.0001 per share for a purchase price of $100.00. The closing of the sale and purchase of the share of Series A Preferred was completed on April 13, 2023.

The share of Series A Preferred was entitled 3.0 billion votes, but had the right to vote only on a proposal submitted to the stockholders of the Company to adopt an amendment, or a series of alternate amendments, to the Company’s Amended and Restated Certificate of Incorporation, as amended, to combine the outstanding shares of Common Stock into a smaller number of shares of Common Stock at a ratio specified in or determined in accordance with the terms of such amendment or series of alternate amendments (“Reverse Stock Split Proposal”), and had no voting rights (i) except with respect to a Reverse Stock Split Proposal and the votes of the share of Series A Preferred were required to be cast for and against such Reverse Stock Split Proposal in the same proportion as shares of Common Stock were voted for and against such Reverse Stock Split Proposal (with any shares of Common Stock that were not voted, whether due to abstentions, broker non-votes or otherwise not counted as votes for or against a Reverse Stock Split Proposal) and (ii) unless the holders of one-third (1/3rd) of the outstanding shares of Common Stock were present and voted, in person or by proxy, at the meeting of stockholders at which the Reverse Stock Split Proposal was submitted for stockholder approval (or any adjournment thereof). The share of Series A Preferred voted together with the Common Stock as a single class on the Reverse Stock Split Proposal at the Company’s 2023 Annual Meeting of Stockholders held on June 14, 2023. The Series A Preferred had no other voting rights, except as may have been required by the General Corporation Law of the State of Delaware. The outstanding share of Series A Preferred was redeemed in whole, for a redemption price of $100.00, paid out of funds lawfully available therefor automatically immediately following the approval by the stockholders of the Reverse Stock Split Proposal on June 14, 2023.

- Definition

The entire disclosure for equity.

+ References

Reference 1: http://www.xbrl.org/2003/role/disclosureRef
-Topic 505
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 13
-Subparagraph (b)
-Publisher FASB
-URI https://asc.fasb.org//1943274/2147481112/505-10-50-13

Reference 2: http://www.xbrl.org/2003/role/disclosureRef
-Topic 505
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 13
-Subparagraph (h)
-Publisher FASB
-URI https://asc.fasb.org//1943274/2147481112/505-10-50-13

Reference 3: http://www.xbrl.org/2003/role/disclosureRef
-Topic 505
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 14
-Subparagraph (b)
-Publisher FASB
-URI https://asc.fasb.org//1943274/2147481112/505-10-50-14

Reference 4: http://www.xbrl.org/2003/role/disclosureRef
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-SubTopic 235
-Name Accounting Standards Codification
-Section 50
-Paragraph 2
-Subparagraph (a)
-Publisher FASB
-URI https://asc.fasb.org//1943274/2147481062/946-235-50-2

Reference 5: http://www.xbrl.org/2003/role/disclosureRef
-Topic 946
-SubTopic 235
-Name Accounting Standards Codification
-Section 50
-Paragraph 2
-Subparagraph (d)
-Publisher FASB
-URI https://asc.fasb.org//1943274/2147481062/946-235-50-2

Reference 6: http://www.xbrl.org/2003/role/disclosureRef
-Topic 946
-SubTopic 505
-Name Accounting Standards Codification
-Section 50
-Paragraph 6
-Publisher FASB
-URI https://asc.fasb.org//1943274/2147481004/946-505-50-6

Reference 7: http://www.xbrl.org/2003/role/disclosureRef
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-SubTopic 40
-Name Accounting Standards Codification
-Section 50
-Paragraph 6
-Subparagraph (a)
-Publisher FASB
-URI https://asc.fasb.org//1943274/2147480237/815-40-50-6

Reference 8: http://www.xbrl.org/2003/role/disclosureRef
-Topic 505
-SubTopic 10
-Name Accounting Standards Codification
-Section S99
-Paragraph 1
-Subparagraph (SX 210.3-04)
-Publisher FASB
-URI https://asc.fasb.org//1943274/2147480008/505-10-S99-1

Reference 9: http://www.xbrl.org/2003/role/disclosureRef
-Topic 235
-SubTopic 10
-Name Accounting Standards Codification
-Section S99
-Paragraph 1
-Subparagraph (SX 210.4-08(e)(1))
-Publisher FASB
-URI https://asc.fasb.org//1943274/2147480678/235-10-S99-1

Reference 10: http://fasb.org/us-gaap/role/ref/legacyRef
-Topic 505
-Name Accounting Standards Codification
-Publisher FASB
-URI https://asc.fasb.org//505/tableOfContent

Reference 11: http://www.xbrl.org/2003/role/disclosureRef
-Topic 505
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-Section 50
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-Publisher FASB
-URI https://asc.fasb.org//1943274/2147481112/505-10-50-13

Reference 12: http://www.xbrl.org/2003/role/disclosureRef
-Topic 505
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-Name Accounting Standards Codification
-Section 50
-Paragraph 13
-Subparagraph (g)
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-URI https://asc.fasb.org//1943274/2147481112/505-10-50-13

Reference 13: http://www.xbrl.org/2003/role/disclosureRef
-Topic 505
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 13
-Subparagraph (i)
-Publisher FASB
-URI https://asc.fasb.org//1943274/2147481112/505-10-50-13

Reference 14: http://www.xbrl.org/2003/role/disclosureRef
-Topic 505
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 14
-Subparagraph (a)
-Publisher FASB
-URI https://asc.fasb.org//1943274/2147481112/505-10-50-14

Reference 15: http://www.xbrl.org/2003/role/disclosureRef
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-Section 50
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Reference 16: http://www.xbrl.org/2003/role/disclosureRef
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Reference 17: http://www.xbrl.org/2003/role/disclosureRef
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-URI https://asc.fasb.org//1943274/2147481112/505-10-50-18

Reference 18: http://www.xbrl.org/2003/role/disclosureRef
-Topic 505
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-Publisher FASB
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Reference 19: http://www.xbrl.org/2003/role/disclosureRef
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-Publisher FASB
-URI https://asc.fasb.org//1943274/2147481112/505-10-50-18

+ Details

Condensed Consolidated Statements of Operations (Unaudited) - USD ($) shares in Thousands, $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2023	Jun. 30, 2022	Jun. 30, 2023	Jun. 30, 2022
Revenue:
Total revenue	$ 8,662	$ 6,670	$ 16,077	$ 12,366
Operating expenses:
Total cost of revenue	6,354	5,199	11,700	10,034
Operating expenses:
Research and development	14,610	11,767	28,547	22,296
Selling, general and administrative	26,936	21,783	52,913	42,060
Total operating expenses	41,546	33,550	81,460	64,356
Loss from operations	(39,238)	(32,079)	(77,083)	(62,024)
Other income (expense):
Interest income	689	192	1,392	301
Interest expense	(74)	(74)	(149)	(151)
Other income (expense)	(256)	(156)	(139)	(188)
Total other income (expense)	359	(38)	1,104	(38)
Loss before income taxes	(38,879)	(32,117)	(75,979)	(62,062)
Benefit (provision) for income taxes	(33)	(41)	(59)	(50)
Net loss	$ (38,912)	$ (32,158)	$ (76,038)	$ (62,112)
Net loss per share, basic (in dollars per share)	$ (1.24)	$ (1.13)	$ (2.46)	$ (2.18)
Net loss per share, diluted (in dollars per share)	$ (1.24)	$ (1.13)	$ (2.46)	$ (2.18)
Weighted-average common shares outstanding, basic (in shares)	31,498	28,555	30,855	28,509
Weighted-average common shares outstanding, diluted (in shares)	31,498	28,555	30,855	28,509
Product revenue
Revenue:
Total revenue	$ 6,609	$ 4,795	$ 12,056	$ 9,001
Operating expenses:
Total cost of revenue	4,752	3,973	8,610	7,549
Service and other revenue
Revenue:
Total revenue	2,053	1,875	4,021	3,365
Operating expenses:
Total cost of revenue	$ 1,602	$ 1,226	$ 3,090	$ 2,485

Commitments and Contingencies - Summary of Undiscounted Future Non-Cancellable Lease Payments Under Leases (Details) $ in Thousands	Jun. 30, 2023 USD ($)
Operating Leases
Remainder of 2023	$ 1,295
2024	2,684
2025	2,788
2026	729
2027	255
Thereafter	0
Total future lease payments	7,751
Less: imputed interest	(971)
Total lease liabilities	6,780
Finance Lease
Remainder of 2023	162
2024	330
2025	338
2026	347
2027	356
Thereafter	5,594
Total future lease payments	7,127
Less: imputed interest	(3,244)
Total lease liabilities	$ 3,883

Organization and Basis of Presentation (Details) $ in Thousands		6 Months Ended
	Aug. 04, 2023	Jun. 30, 2023 USD ($) segment reportingUnit	Jun. 30, 2022 USD ($)	Dec. 31, 2022 USD ($)
Subsequent Event [Line Items]
Cash and cash equivalents		$ 14,856	$ 27,159	$ 5,091
Investments		62,206		108,095
Working capital		89,100
Accumulated deficit		424,751		$ 348,715
Net cash used in operating activities		$ 69,109	$ 60,826
Number of operating segments \| segment		1
Number of reporting units \| reportingUnit		1
Subsequent Event
Subsequent Event [Line Items]
Reverse stock split, conversion ratio	0.1

Investments and Fair Value Measurements - Financial Assets and Liabilities (Details) - Fair Value, Recurring - USD ($) $ in Thousands	Jun. 30, 2023	Dec. 31, 2022
Contingent consideration
Fair Value, Balance Sheet Grouping, Financial Statement Captions [Line Items]
Liabilities	$ 24,570	$ 22,352
Total investments
Fair Value, Balance Sheet Grouping, Financial Statement Captions [Line Items]
Assets	62,206	108,095
Total investments \| Commercial paper
Fair Value, Balance Sheet Grouping, Financial Statement Captions [Line Items]
Assets	13,403	20,020
Total investments \| Corporate notes/bonds
Fair Value, Balance Sheet Grouping, Financial Statement Captions [Line Items]
Assets	46,816	86,094
Total investments \| Securities of government sponsored entities
Fair Value, Balance Sheet Grouping, Financial Statement Captions [Line Items]
Assets	1,987	1,981
Money market funds
Fair Value, Balance Sheet Grouping, Financial Statement Captions [Line Items]
Assets	7,962	1,868
Level 1 \| Contingent consideration
Fair Value, Balance Sheet Grouping, Financial Statement Captions [Line Items]
Liabilities	0	0
Level 1 \| Total investments
Fair Value, Balance Sheet Grouping, Financial Statement Captions [Line Items]
Assets	0	0
Level 1 \| Total investments \| Commercial paper
Fair Value, Balance Sheet Grouping, Financial Statement Captions [Line Items]
Assets	0	0
Level 1 \| Total investments \| Corporate notes/bonds
Fair Value, Balance Sheet Grouping, Financial Statement Captions [Line Items]
Assets		0
Level 1 \| Total investments \| Securities of government sponsored entities
Fair Value, Balance Sheet Grouping, Financial Statement Captions [Line Items]
Assets	0
Level 1 \| Money market funds
Fair Value, Balance Sheet Grouping, Financial Statement Captions [Line Items]
Assets	7,962	1,868
Level 2 \| Contingent consideration
Fair Value, Balance Sheet Grouping, Financial Statement Captions [Line Items]
Liabilities	0	0
Level 2 \| Total investments
Fair Value, Balance Sheet Grouping, Financial Statement Captions [Line Items]
Assets	62,206	108,095
Level 2 \| Total investments \| Commercial paper
Fair Value, Balance Sheet Grouping, Financial Statement Captions [Line Items]
Assets	13,403	20,020
Level 2 \| Total investments \| Corporate notes/bonds
Fair Value, Balance Sheet Grouping, Financial Statement Captions [Line Items]
Assets	46,816	86,094
Level 2 \| Total investments \| Securities of government sponsored entities
Fair Value, Balance Sheet Grouping, Financial Statement Captions [Line Items]
Assets	1,987	1,981
Level 2 \| Money market funds
Fair Value, Balance Sheet Grouping, Financial Statement Captions [Line Items]
Assets	0	0
Level 3 \| Contingent consideration
Fair Value, Balance Sheet Grouping, Financial Statement Captions [Line Items]
Liabilities	24,570	22,352
Level 3 \| Total investments
Fair Value, Balance Sheet Grouping, Financial Statement Captions [Line Items]
Assets	0	0
Level 3 \| Total investments \| Commercial paper
Fair Value, Balance Sheet Grouping, Financial Statement Captions [Line Items]
Assets	0	0
Level 3 \| Total investments \| Corporate notes/bonds
Fair Value, Balance Sheet Grouping, Financial Statement Captions [Line Items]
Assets	0	0
Level 3 \| Total investments \| Securities of government sponsored entities
Fair Value, Balance Sheet Grouping, Financial Statement Captions [Line Items]
Assets	0
Level 3 \| Money market funds
Fair Value, Balance Sheet Grouping, Financial Statement Captions [Line Items]
Assets	$ 0	$ 0

Stockholders’ Equity and Stock-Based Compensation - Recognized Stock-Based Compensation Expense (Details) - USD ($) $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2023	Jun. 30, 2022	Jun. 30, 2023	Jun. 30, 2022
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Total stock-based compensation expense	$ 3,932	$ 5,777	$ 7,814	$ 10,879
Cost of product revenue
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Total stock-based compensation expense	154	0	256	0
Cost of service and other revenue
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Total stock-based compensation expense	44	0	88	0
Research and development
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Total stock-based compensation expense	1,301	3,468	2,658	6,795
General and administrative
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Total stock-based compensation expense	$ 2,433	$ 2,309	$ 4,812	$ 4,084

- Definition

Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table.

+ References

Reference 1: http://www.xbrl.org/2003/role/disclosureRef
-Topic 718
-SubTopic 10
-Name Accounting Standards Codification
-Section 35
-Paragraph 1D
-Publisher FASB
-URI https://asc.fasb.org//1943274/2147480483/718-10-35-1D

Reference 2: http://www.xbrl.org/2003/role/disclosureRef
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-URI https://asc.fasb.org//1943274/2147480429/718-10-50-2

Reference 23: http://www.xbrl.org/2003/role/disclosureRef
-Topic 718
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 2
-Subparagraph (e)(2)
-Publisher FASB
-URI https://asc.fasb.org//1943274/2147480429/718-10-50-2

Reference 24: http://www.xbrl.org/2003/role/disclosureRef
-Topic 718
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 2
-Subparagraph (f)(2)(i)
-Publisher FASB
-URI https://asc.fasb.org//1943274/2147480429/718-10-50-2

Reference 25: http://www.xbrl.org/2003/role/disclosureRef
-Topic 718
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 2
-Subparagraph (f)(2)(ii)
-Publisher FASB
-URI https://asc.fasb.org//1943274/2147480429/718-10-50-2

Reference 26: http://www.xbrl.org/2003/role/disclosureRef
-Topic 718
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 2
-Subparagraph (f)(2)(iii)
-Publisher FASB
-URI https://asc.fasb.org//1943274/2147480429/718-10-50-2

Reference 27: http://www.xbrl.org/2003/role/disclosureRef
-Topic 718
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 2
-Subparagraph (f)(2)(iv)
-Publisher FASB
-URI https://asc.fasb.org//1943274/2147480429/718-10-50-2

Reference 28: http://www.xbrl.org/2003/role/disclosureRef
-Topic 718
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 2
-Subparagraph (f)(2)(v)
-Publisher FASB
-URI https://asc.fasb.org//1943274/2147480429/718-10-50-2

+ Details

Stockholders’ Equity and Stock-Based Compensation - Assumptions (Details)	3 Months Ended		6 Months Ended
	Jun. 30, 2023	Jun. 30, 2022	Jun. 30, 2023	Jun. 30, 2022
Share-Based Payment Arrangement [Abstract]
Risk-free interest rate	3.90%	2.80%	3.90%	2.10%
Expected volatility	80.50%	70.60%	74.40%	70.20%
Expected term (in years)	5 years 6 months	5 years 8 months 12 days	5 years 10 months 24 days	6 years
Expected dividend yield	0.00%	0.00%	0.00%	0.00%

Balance Sheet Account Details - Schedule of Allowance for Credit Losses (Details) $ in Thousands	6 Months Ended
	Jun. 30, 2023 USD ($)
Accounts Receivable, Allowance for Credit Loss [Roll Forward]
Beginning balance	$ (293)
Provision for expected credit loss	(5)
Write-offs and payments	36
Ending balance	$ (262)

Revenue Recognition - Narrative (Details) - Geographic Concentration Risk - Revenue from Contract with Customer	3 Months Ended		6 Months Ended
	Jun. 30, 2023	Jun. 30, 2022	Jun. 30, 2023	Jun. 30, 2022
Disaggregation of Revenue [Line Items]
Concentration risk percentage	100.00%	100.00%	100.00%	100.00%
United States
Disaggregation of Revenue [Line Items]
Concentration risk percentage	39.10%	37.40%	40.10%	40.90%
China
Disaggregation of Revenue [Line Items]
Concentration risk percentage	15.00%	19.30%	10.20%	12.90%

- Definition

Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table.

+ References + Details

Balance Sheet Account Details - Schedule of Accrued Expenses (Details) - USD ($) $ in Thousands	Jun. 30, 2023	Dec. 31, 2022
Organization, Consolidation and Presentation of Financial Statements [Abstract]
Compensation expenses	$ 5,917	$ 7,002
Customer deposits	17	17
Taxes payable	897	825
Insurance	125	613
Professional fees and royalties	153	210
Warranty liabilities	640	489
Accrued clinical study fees	150	250
Other	417	1,146
Accrued expenses	$ 8,316	$ 10,552

Condensed Consolidated Balance Sheets - USD ($) $ in Thousands	Jun. 30, 2023	Dec. 31, 2022
Current assets:
Cash and cash equivalents	$ 14,856	$ 5,091
Investments	62,206	108,095
Accounts receivable, net	7,613	7,022
Inventory	32,453	29,761
Prepaid expenses and other current assets	5,447	7,329
Total current assets	122,575	157,298
Restricted cash	400	400
Property and equipment, net	20,263	18,029
Operating lease right-of-use assets	6,697	7,222
Finance lease right-of-use assets	3,606	3,707
Intangible assets, net	37,559	41,143
Goodwill	77,281	77,289
Other long-term assets	3,000	2,414
Total assets	271,381	307,502
Current liabilities:
Accounts payable	11,912	12,534
Accrued expenses	8,316	10,552
Contract liabilities	978	871
Operating lease liability	2,014	2,260
Finance lease liability	279	285
Contingent consideration	10,000	9,382
Total current liabilities	33,499	35,884
Operating lease liability, net of current portion	4,766	5,504
Finance lease liability, net of current portion	3,604	3,619
Contingent consideration, net of current portion	14,570	12,970
Long-term contract liabilities	186	127
Total liabilities	56,625	58,104
Commitments and contingencies (Note 6)
Stockholders’ equity:
Preferred stock, $0.0001 par value; 10,000,000 shares authorized at June 30, 2023 and December 31, 2022; no shares issued and outstanding at June 30, 2023 and December 31, 2022	0	0
Common stock, $0.0001 par value, 400,000,000 shares authorized at June 30, 2023 and December 31, 2022; 33,240,000 and 29,718,000 shares issued and outstanding at June 30, 2023 and December 31, 2022, respectively	3	3
Additional paid-in capital	639,814	599,234
Accumulated deficit	(424,751)	(348,715)
Accumulated other comprehensive loss	(310)	(1,124)
Total stockholders’ equity	214,756	249,398
Total liabilities and stockholders’ equity	$ 271,381	$ 307,502

Commitments and Contingencies

6 Months Ended

Jun. 30, 2023

Commitments and Contingencies Disclosure [Abstract]

Commitments and Contingencies

The Company has entered into various operating lease agreements and a finance lease agreement, primarily relating to our office, laboratory, and manufacturing space. See Note 11 – Commitments and Contingencies, subsection titled “Leases”, in Part II, Item 8 of the Annual Report on Form 10-K for the year ended December 31, 2022 for information regarding the Company’s lease agreements.

The future minimum payments under non-cancellable operating and finance leases as of June 30, 2023, are as follows:


	Operating Leases		Finance Lease
Remainder of 2023	$	1,295,000	$	162,000
2024	2,684,000		330,000
2025	2,788,000		338,000
2026	729,000		347,000
2027	255,000		356,000
Thereafter	—		5,594,000
Total future lease payments	7,751,000		7,127,000
Less: imputed interest	(971,000)		(3,244,000)
Total lease liabilities	$	6,780,000	$	3,883,000

Litigation

From time to time, the Company may be subject to potential liabilities under various claims and legal actions that are pending or may be asserted. These matters arise in the ordinary course and conduct of the business. The Company regularly assesses contingencies to determine the degree of probability and range of possible loss for potential accrual in the unaudited condensed consolidated financial statements. An estimated loss contingency is accrued in the unaudited condensed consolidated financial statements if it is probable that a liability has been incurred and the amount of the loss can be reasonably estimated. Based on the Company’s assessment, it currently does not have any material loss exposure as it is not a defendant in any claims or legal actions.

Contingent Consideration

See Note 8 to our unaudited condensed consolidated financial statements for a discussion of the contingent consideration liability.

Investments and Fair Value Measurements - Amortized Cost and Unrealized Gains (Losses) (Details) - USD ($) $ in Thousands	Jun. 30, 2023	Dec. 31, 2022
Amortized Cost
Less than 1 year	$ 62,505	$ 94,914
Total	62,505	109,182
Unrealized Gains
Less than 1 year	0	1
Total	0	1
Unrealized Losses
Less than 1 year	(299)	(1,000)
Total	(299)	(1,088)
Aggregate Estimated Fair Value
Less than 1 year	62,206	93,915
Total	62,206	108,095
Commercial paper
Amortized Cost
Less than 1 year	13,420	20,093
Unrealized Gains
Less than 1 year	0	0
Unrealized Losses
Less than 1 year	(16)	(73)
Aggregate Estimated Fair Value
Less than 1 year	13,404	20,020
Corporate notes/bonds
Amortized Cost
Less than 1 year	47,086	72,823
Due after one year through five years	0	14,268
Unrealized Gains
Less than 1 year	0	1
Due after one year through five years	0	0
Unrealized Losses
Less than 1 year	(271)	(911)
Due after one year through five years	0	(88)
Aggregate Estimated Fair Value
Less than 1 year	46,815	71,913
Due after one year through five years	0	14,180
Securities of government sponsored entities
Amortized Cost
Less than 1 year	1,999	1,998
Unrealized Gains
Less than 1 year	0	0
Unrealized Losses
Less than 1 year	(12)	(16)
Aggregate Estimated Fair Value
Less than 1 year	$ 1,987	$ 1,982

Stockholders’ Equity and Stock-Based Compensation (Tables)

6 Months Ended

Jun. 30, 2023

Share-Based Payment Arrangement [Abstract]

Schedule of Warrant Activity

A summary of the Company’s warrant activity during the six months ended June 30, 2023 was as follows:


	Shares of Stock under Warrants	Weighted- Average Exercise Price		Weighted- Average Remaining Contractual Term	Aggregate Intrinsic Value
Outstanding at January 1, 2023	436,000	$	59.60	0.76	$	273,000
Granted	—	—		—	—
Exercised	—	—		—	—
Canceled	—	—		—	—
Outstanding at June 30, 2023	436,000	$	59.60	0.27	$	—

Schedule of Stock Option Activity

A summary of the Company’s stock option activity during the six months ended June 30, 2023 was as follows:


	Shares of Stock under Stock Options	Weighted- Average Exercise Price		Weighted- Average Remaining Contractual Term	Aggregate Intrinsic Value
Outstanding at January 1, 2023	2,402,000	$	32.80	8.50	$	2,068,000
Granted	1,181,000	14.10		—
Exercised	(4,000)	5.50		—	25,000
Canceled	(233,000)	28.20		—
Outstanding at June 30, 2023	3,346,000	$	26.60	8.63	$	148,000
Vested and exercisable at June 30, 2023	1,108,000	$	33.90	7.68	$	131,000

Schedule of Recognized Stock-Based Compensation Expense

The Company recognized stock-based compensation expense for the periods presented as follows:


	Three Months Ended June 30,				Six Months Ended June 30,
	2023		2022		2023		2022
Cost of product revenue	$	154,000	$	—	$	256,000	$	—
Cost of service and other revenue	44,000		—		88,000		$	—
Research and development	1,301,000		3,468,000		2,658,000		$	6,795,000
General and administrative	2,433,000		2,309,000		4,812,000		4,084,000
Total stock-based compensation expense	$	3,932,000	$	5,777,000	$	7,814,000	$	10,879,000

Schedule of Weighted-Average Assumptions in Black -Scholes Option Pricing Model

The weighted-average assumptions used in the Black-Scholes option pricing model to determine the fair value of the employee stock option grants during the periods presented were as follows:


	Three Months Ended June 30,				Six Months Ended June 30,
	2023		2022		2023		2022
Risk-free interest rate	3.9	%	2.8	%	3.9	%	2.1	%
Expected volatility	80.5	%	70.6	%	74.4	%	70.2	%
Expected term (in years)	5.5		5.7		5.9		6.0
Expected dividend yield	0.0	%	0.0	%	0.0	%	0.0	%

Schedule of Restricted Stock Units and Performance Stock Units

The following table summarizes RSU activity during the six months ended June 30, 2023:


	Stock Units	Weighted- Average Grant Date Fair Value per Share
Outstanding at January 1, 2023	10,000	$	47.40
Granted	247,000	16.30
Released	(10,000)	47.40
Forfeited	(17,000)	16.30
Outstanding at June 30, 2023	230,000	$	16.30

The following table summarizes PSU activity during the six months ended June 30, 2023:


	Stock Units	Weighted- Average Grant Date Fair Value per Share
Outstanding at January 1, 2023	29,000	$	47.4
Granted	—	—
Released	—	—
Forfeited	—	—
Outstanding at June 30, 2023	29,000	$	47.4

Acquisitions - Identifiable Intangible Assets (Details) - Purigen $ in Thousands	Nov. 30, 2022 USD ($)
Business Acquisition [Line Items]
Intangible assets	$ 20,000
Developed technology
Business Acquisition [Line Items]
Intangible assets	18,800
Customer relationships
Business Acquisition [Line Items]
Intangible assets	200
Tradename
Business Acquisition [Line Items]
Intangible assets	$ 1,000

Revenue Recognition - Remaining Performance Obligations (Details) - USD ($) $ in Millions	3 Months Ended		6 Months Ended
	Jun. 30, 2023	Jun. 30, 2022	Jun. 30, 2023	Jun. 30, 2022
Revenue, Remaining Performance Obligation, Expected Timing of Satisfaction [Line Items]
Performance obligation	$ 1.2		$ 1.2
Revenue recognized excluding deferred amounts	$ 0.4	$ 0.2	$ 1.1	$ 0.5
Revenue, Remaining Performance Obligation, Expected Timing of Satisfaction, Start Date [Axis]: 2023-07-01
Revenue, Remaining Performance Obligation, Expected Timing of Satisfaction [Line Items]
Performance obligation, percentage	61.70%		61.70%
Timing of satisfaction of remaining performance obligation	6 months		6 months
Revenue, Remaining Performance Obligation, Expected Timing of Satisfaction, Start Date [Axis]: 2024-01-01
Revenue, Remaining Performance Obligation, Expected Timing of Satisfaction [Line Items]
Performance obligation, percentage	31.20%		31.20%
Timing of satisfaction of remaining performance obligation	1 year		1 year
Revenue, Remaining Performance Obligation, Expected Timing of Satisfaction, Start Date [Axis]: 2025-01-01
Revenue, Remaining Performance Obligation, Expected Timing of Satisfaction [Line Items]
Performance obligation, percentage	7.10%		7.10%
Timing of satisfaction of remaining performance obligation	1 year		1 year

Acquisitions - Acquisition Purchase Price (Details) - Purigen $ in Thousands	1 Months Ended
	Nov. 30, 2022 USD ($)
Business Acquisition [Line Items]
Cash	$ 32,034
Estimated fair value of milestone consideration	12,970
Return of cash to buyer from escrow	(95)
Total purchase price	$ 44,909

Investments and Fair Value Measurements

6 Months Ended

Jun. 30, 2023

Fair Value Disclosures [Abstract]

Investments and Fair Value Measurements

Investments and Fair Value MeasurementsThe Company holds investment securities that consist of highly liquid, investment grade debt securities. The Company determines the fair value of its investment securities based upon one or more valuations reported by its investment accounting and reporting service provider. The investment service provider values the securities using a hierarchical security pricing model that relies primarily on valuations provided by an industry-recognized valuation service. Such valuations may be based on trade prices in active markets for identical assets or liabilities (Level 1 inputs) or valuation models using inputs that are observable either directly or indirectly (Level 2 inputs), such as quoted prices for similar assets or liabilities, yield curves, volatility factors,

credit spreads, default rates, loss severity, current market and contractual prices for the underlying instruments or debt, and broker and dealer quotes, as well as other relevant economic measures.

The following table presents the Company’s financial assets and liabilities measured at fair value on a recurring basis as of June 30, 2023 and December 31, 2022:


	June 30, 2023
	Total Fair Value and Carrying Value on Balance Sheet		Fair Value Measurement Category
			Level 1		Level 2		Level 3
Assets:
Commercial paper	$	13,403,000	$	—	$	13,403,000	$	—
Corporate notes/bonds	46,816,000				46,816,000		—
Securities of government sponsored entities	1,987,000		—		1,987,000		—
Total investments:	$	62,206,000	$	—	$	62,206,000	$	—
Money market funds	$	7,962,000	$	7,962,000	$	—	$	—
Liabilities:
Contingent consideration	$	24,570,000	$	—	$	—	$	24,570,000


	December 31, 2022
	Total Fair Value and Carrying Value on Balance Sheet		Fair Value Measurement Category
			Level 1		Level 2		Level 3
Assets:
Commercial paper	$	20,020,000	$	—	$	20,020,000	$	—
Corporate notes/bonds	86,094,000		—		86,094,000		—
Securities of government sponsored entities	1,981,000				1,981,000
Total investments:	$	108,095,000	$	—	$	108,095,000	$	—
Money market funds	$	1,868,000	$	1,868,000	$	—	$	—
Liabilities:
Contingent consideration	$	22,352,000	$	—	$	—	$	22,352,000

Money Market Funds are classified as cash equivalents on the unaudited condensed consolidated balance sheet.

Contingent Consideration

Contingent consideration relates to the acquisitions of BioDiscovery and Purigen. The outcome of the milestone consideration for all contingent consideration liabilities is binary, meaning the milestones are either achieved or not achieved, and the only other variable factor is the timing of when the milestones are achieved. The fair value measurement of the contingent consideration liabilities is based on significant inputs not observed in the market (Level 3 inputs). These unobservable inputs represent a Level 3 measurement because they are supported by little or no market activity and reflect the Company’s assumptions in measuring fair value.

The fair value of the BioDiscovery contingent consideration liability is reassessed on a quarterly basis using a probability weighted model. Assumptions used to estimate the acquisition date fair value of the contingent consideration related to the acquisition of BioDiscovery include the probability of achieving, or changes in timing, of certain milestones, and a discount rate. As of June 30, 2023 a discount rate of 3% was used. The Company determined the fair value of the BioDiscovery milestone consideration using a scenario-based technique, as the trigger for payment is event driven. The Company determined it is highly likely that the milestone related to the BioDiscovery acquisition will be achieved and therefore used a 100% probability factor which is applied to the $10.0 million milestone consideration. The change in fair value of the contingent consideration during the six months ended June 30, 2023 was due to the passage of time, in addition to accreting the balance up to the full value of the milestone to be paid of $10.0 million for a total change of $0.6 million.

Contingent consideration liabilities related to the Purigen milestones are related to the achievement of two independent milestones with aggregate possible milestone payments totaling $32.0 million.

The fair value of the Purigen milestones are reassessed on a quarterly basis using a probability weighted model and a Monte Carlo Simulation. Assumptions used to estimate the acquisition date fair value of the milestones using a probability weighted model include the probability of achieving, or changes in timing, of independent milestones, and a discount rate of 14%. The Company determined the fair value of this milestone consideration using a scenario-based technique, as the trigger for payment is event driven. The Company determined the likelihood of each independent milestone and used probability factors ranging from 20% to 80% which were applied to the individual payments. A Monte Carlo Simulation was performed to determine the likelihood that the milestone will be achieved and was applied to the milestone consideration payment. The change in fair value of the contingent consideration during the six months ended June 30, 2023 was $1.6 million

Changes in estimated fair value of contingent consideration liability in the six months ended June 30, 2023 is as follows:


	Contingent Consideration Liability (Level 3 Measurement)
Balance as of January 1, 2023	$	22,352,000
Liability recorded as a result of current period acquisition	—
Change in estimated fair value, recorded in selling, general and administrative expenses	2,218,000
Cash payments	—
Balance as of June 30, 2023	$	24,570,000

Changes in estimated fair value of contingent consideration liability in the six months ended June 30, 2022 is as follows:


	Contingent Consideration Liability (Level 3 Measurement)
Balance as of January 1, 2022	$	9,066,000
Liability recorded as a result of current period acquisition	—
Change in estimated fair value, recorded in selling, general and administrative expenses	158,000
Cash payments	—
Balance as of June 30, 2022	$	9,224,000

Available for Sale Investments

The Company invests its excess cash in U.S. Treasury and agency securities, corporate debt securities, and commercial paper, which are classified as available-for-sale investments. These investments are carried at fair value and are included in the tables below. The Company records an allowance for credit losses when unrealized losses are due to credit-related factors. At each reporting date, the Company evaluates securities with unrealized losses to determine whether such losses, if any, are due to credit-related factors. The Company evaluates, among others, whether the Company has the intention to sell any of these investments and whether it is not more likely than not that the Company will be required to sell any of them before recovery of the amortized cost basis. Neither of these criteria were met in any period presented. The credit ratings of the securities held remain of the highest quality. Moreover, the Company continues to receive payments of interest and principal as they become due, and our expectation is that those payments will continue to be received timely. Based on this evaluation, as of June 30, 2023 and December 31, 2022, the Company determined that unrealized losses of the below securities were primarily attributable to changes in interest rates and non-credit related factors. As such, no allowances for credit losses were recorded during these periods.

As of June 30, 2023 and December 31, 2022, the Company held 15 and 16 securities, respectively, which have been in an unrealized loss position for a period of less than 12 months. As of June 30, 2023 and December 31, 2022, the Company held 11 and 24 securities, respectively, which have been in an unrealized loss position for a period of greater than 12 months.

Realized gains and losses are calculated using the specific identification method and recorded in other income (expense) in the Company’s unaudited condensed consolidated statements of operations and comprehensive loss. The Company has the ability, if necessary, to liquidate any of its cash equivalents and marketable securities to meet its liquidity needs in the next 12 months.

Interest receivable as of June 30, 2023 and December 31, 2022 was $0.4 million and $0.5 million, respectively, and is recorded as a component of prepaid expenses and other current assets on the unaudited condensed consolidated balance sheets.

As of June 30, 2023, the following table summarizes the amortized cost and the unrealized gains/losses of the available for sale securities:


	Remaining Contractual Maturity (in years)	Amortized Cost		Unrealized Gains		Unrealized Losses		Aggregate Estimated Fair Value
Commercial paper	Less than 1	$	13,420,000	$	—	$	(16,000)	$	13,404,000
Corporate notes/bonds	Less than 1	47,086,000		—		(271,000)		46,815,000
Securities of government sponsored entities	Less than 1	1,999,000		—		(12,000)		1,987,000
Total maturity less than 1 year		$	62,505,000	$	—	$	(299,000)	$	62,206,000
Corporate notes/bonds	1 to 5	—		—		—		—
Total		$	62,505,000	$	—	$	(299,000)	$	62,206,000

As of December 31, 2022, the following table summarizes the amortized cost and the unrealized gains/losses of the available for sale securities:


	Remaining Contractual Maturity (in years)	Amortized Cost		Unrealized Gains		Unrealized Losses		Aggregate Estimated Fair Value
Commercial paper	Less than 1	$	20,093,000	$	—	$	(73,000)	$	20,020,000
Corporate notes/bonds	Less than 1	72,823,000		1,000		(911,000)		71,913,000
Securities of government sponsored entities	Less than 1	1,998,000		—		(16,000)		1,982,000
Total maturity less than 1 year		$	94,914,000	$	1,000	$	(1,000,000)	$	93,915,000
Corporate notes/bonds	1 to 5	14,268,000		—		(88,000)		14,180,000
Total		$	109,182,000	$	1,000	$	(1,088,000)	$	108,095,000

As of June 30, 2023, the following table summarizes available-for-sale securities in an unrealized loss position with no credit losses reported:


	Less Than 12 Months				12 Months or Greater				Total
	Fair Value		Gross Unrealized Loss		Fair Value		Gross Unrealized Loss		Fair Value		Gross Unrealized Loss
Commercial paper	$	13,403,000	$	(16,000)	$	—	$	—	$	13,403,000	$	(16,000)
Corporate Notes/Bonds	10,241,000		(39,000)		36,575,000		(232,000)		46,816,000		(271,000)
Securities of Government Sponsored Entities	1,987,000		(12,000)		—		—		1,987,000		(12,000)
Total	$	25,631,000	$	(67,000)	$	36,575,000	$	(232,000)	$	62,206,000	$	(299,000)

As of December 31, 2022, the following table summarizes available-for-sale securities in an unrealized loss position with no credit losses reported:


	Less Than 12 Months				12 Months or Greater				Total
	Fair Value		Gross Unrealized Loss		Fair Value		Gross Unrealized Loss		Fair Value		Gross Unrealized Loss
Commercial paper	$	20,020,000	$	(73,000)	$	—	$	—	$	20,020,000	$	(73,000)
Corporate Notes/Bonds	9,661,000		(27,000)		74,452,000		(972,000)		84,113,000		(999,000)
Securities of Government Sponsored Entities	1,981,000		(16,000)		—		—		1,981,000		(16,000)
Total	$	31,662,000	$	(116,000)	$	74,452,000	$	(972,000)	$	106,114,000	$	(1,088,000)

- Definition

The entire disclosure for the fair value of financial instruments (as defined), including financial assets and financial liabilities (collectively, as defined), and the measurements of those instruments as well as disclosures related to the fair value of non-financial assets and liabilities. Such disclosures about the financial instruments, assets, and liabilities would include: (1) the fair value of the required items together with their carrying amounts (as appropriate); (2) for items for which it is not practicable to estimate fair value, disclosure would include: (a) information pertinent to estimating fair value (including, carrying amount, effective interest rate, and maturity, and (b) the reasons why it is not practicable to estimate fair value; (3) significant concentrations of credit risk including: (a) information about the activity, region, or economic characteristics identifying a concentration, (b) the maximum amount of loss the entity is exposed to based on the gross fair value of the related item, (c) policy for requiring collateral or other security and information as to accessing such collateral or security, and (d) the nature and brief description of such collateral or security; (4) quantitative information about market risks and how such risks are managed; (5) for items measured on both a recurring and nonrecurring basis information regarding the inputs used to develop the fair value measurement; and (6) for items presented in the financial statement for which fair value measurement is elected: (a) information necessary to understand the reasons for the election, (b) discussion of the effect of fair value changes on earnings, (c) a description of [similar groups] items for which the election is made and the relation thereof to the balance sheet, the aggregate carrying value of items included in the balance sheet that are not eligible for the election; (7) all other required (as defined) and desired information.

+ References + Details

Acquisitions - Fair Value of Tangible and Identifiable Assets Acquired and Liabilities Assumed (Details) - USD ($) $ in Thousands	Jun. 30, 2023	Dec. 31, 2022	Nov. 30, 2022
Business Acquisition [Line Items]
Goodwill	$ 77,281	$ 77,289
Purigen
Business Acquisition [Line Items]
Cash & cash equivalents			$ 290
Accounts receivable			259
Inventory			944
Prepaid expenses and other current assets			184
Property and equipment, net			805
Restricted cash			400
Operating lease right-of-use assets			1,636
Other long-term assets			533
Intangible assets			20,000
Goodwill			22,646
Accounts payable and other accrued liabilities			(1,152)
Operating lease liability (short-term and long-term)			(1,636)
Net assets acquired			$ 44,909

Stockholders’ Equity and Stock-Based Compensation - Warrant Activity (Details) - USD ($) $ / shares in Units, shares in Thousands, $ in Thousands	6 Months Ended	12 Months Ended
	Jun. 30, 2023	Dec. 31, 2022
Shares of Stock under Warrants
Beginning balance (in shares)	436
Granted (in shares)	0
Exercised (in shares)	0
Canceled (in shares)	0
Ending balance (in shares)	436	436
Weighted- Average Exercise Price
Beginning balance (in dollars per share)	$ 59.60
Ending balance (in dollars per share)	$ 59.60	$ 59.60
Weighted- Average Remaining Contractual Term
Balance	3 months 7 days	9 months 3 days
Aggregate Intrinsic Value
Beginning balance	$ 273
Ending balance	$ 0	$ 273

Net Loss Per Share

6 Months Ended

Jun. 30, 2023

Earnings Per Share [Abstract]

Net Loss Per Share

Net Loss Per ShareBasic net loss per share is calculated by dividing the net loss by the weighted-average number of common shares outstanding for the period. Diluted net loss per share is computed by dividing the net loss by the weighted average number of common shares and common share equivalents outstanding for the period. Common share equivalents are only included when their effect is dilutive. The Company’s potentially dilutive securities which include outstanding warrants to purchase stock, restricted stock units (“RSUs”), performance stock units (“PSUs”), and outstanding stock options under the Company’s equity incentive plans have been excluded from the computation of diluted net loss per share as they would be anti-dilutive to the net loss per share. Restricted stock is treated as outstanding for accounting purposes. For all periods presented, there is no difference in the

number of shares used to calculate basic and diluted shares outstanding because all potentially dilutive securities were anti-dilutive.

Potentially dilutive securities not included in the calculation of diluted net loss per share attributable to common stockholders because to do so would be anti-dilutive are as follows (in common stock equivalent shares):


	June 30, 2023	June 30, 2022
Stock options	3,346,000	2,359,000
Unvested restricted stock	—	384,000
Warrants	436,000	436,000
RSUs	230,000	23,000
PSUs	29,000	29,000
Total	4,041,000	3,231,000

Commitment and Contingencies (Tables)

6 Months Ended

Jun. 30, 2023

Commitments and Contingencies Disclosure [Abstract]

Schedule of Lessee, Operating Lease, Liability, Maturity

The future minimum payments under non-cancellable operating and finance leases as of June 30, 2023, are as follows:


	Operating Leases		Finance Lease
Remainder of 2023	$	1,295,000	$	162,000
2024	2,684,000		330,000
2025	2,788,000		338,000
2026	729,000		347,000
2027	255,000		356,000
Thereafter	—		5,594,000
Total future lease payments	7,751,000		7,127,000
Less: imputed interest	(971,000)		(3,244,000)
Total lease liabilities	$	6,780,000	$	3,883,000

Stockholders’ Equity and Stock-Based Compensation - Narrative (Details) $ / shares in Units, $ in Millions							1 Months Ended			3 Months Ended	6 Months Ended
	Aug. 04, 2023 $ / shares	Apr. 13, 2023 vote $ / shares shares	Mar. 09, 2023 USD ($)	Feb. 15, 2023 installment $ / shares shares	Oct. 04, 2022 USD ($) $ / shares	Mar. 23, 2021 USD ($)	Aug. 09, 2023 USD ($) $ / shares shares	Aug. 31, 2022 USD ($) $ / shares shares	Oct. 31, 2021 $ / shares shares	Jun. 30, 2023 USD ($) $ / shares	Jun. 30, 2023 USD ($) $ / shares shares	Dec. 31, 2022 $ / shares
Class of Stock [Line Items]
Number of shares issued (in shares) \| shares								700,000			3,500,000
Average share price (in dollars per share)								$ 34.59		$ 9.56	$ 9.56
Net proceeds \| $								$ 23.1			$ 33.5
Offering costs \| $								$ 0.6		$ 0.8	$ 0.8
Weighted-average grant date fair value (in dollars per share)										$ 5.36	$ 9.47
Granted (in shares) \| shares											1,181,000
Granted (in dollars per share)											$ 14.10
Preferred stock, par value (in dollars per share)										0.0001	$ 0.0001	$ 0.0001
Reverse stock split, percentage of outstanding common stock are present		33.00%
Subsequent Event
Class of Stock [Line Items]
Reverse stock split, conversion ratio	0.1
Reverse stock split, multiplier, per share (in dollars per share)	$ 5.90
Number of shares issued (in shares) \| shares							2,100,000
Average share price (in dollars per share)							$ 6.16
Net proceeds \| $							$ 13.0
Offering costs \| $							$ 0.3
Series A Preferred Stock
Class of Stock [Line Items]
Preferred stock, number of votes \| vote		3,000,000,000
Preferred stock, redemption price (in dollars per share)		$ 100.00
Executive Officer
Class of Stock [Line Items]
Granted (in shares) \| shares				300,000
Granted (in dollars per share)				$ 16.30
David Barker \| Series A Preferred Stock
Class of Stock [Line Items]
Average share price (in dollars per share)		$ 100.00
Stock issued during period (in shares) \| shares		1
Preferred stock, par value (in dollars per share)		$ 0.0001
Restricted Stock
Class of Stock [Line Items]
Grant fair value (in dollars per share)					$ 20.40
Reduction in stock-based compensation cost from modification \| $					$ 15.8
Vesting period				4 years
Restricted Stock \| Vesting on October 18, 2022
Class of Stock [Line Items]
Granted vesting percentage									33.00%
Restricted Stock \| Vesting every three months following October 18, 2022
Class of Stock [Line Items]
Granted vesting percentage									8.00%
Restricted Stock \| Executive Officer
Class of Stock [Line Items]
Granted (in shares) \| shares				100,000
Restricted Stock \| BioDiscovery
Class of Stock [Line Items]
Units granted (in shares) \| shares									500,000
Granted (in dollars per share)									$ 52.00
RSUs
Class of Stock [Line Items]
Units granted (in shares) \| shares											247,000
Granted (in dollars per share)											$ 16.30
Grant fair value (in dollars per share)										16.30	$ 16.30	47.40
Total intrinsic value \| $											$ 0.5
Weighted average remaining contractual term											3 years 7 months 6 days
RSUs \| Executive Officer
Class of Stock [Line Items]
Number of successive annual installments \| installment				3
PSUs
Class of Stock [Line Items]
Units granted (in shares) \| shares											0
Granted (in dollars per share)											$ 0
Grant fair value (in dollars per share)										$ 47.4	$ 47.4	$ 47.4
Weighted average remaining contractual term											6 months
Option \| Executive Officer
Class of Stock [Line Items]
Vesting period				48 months
Cowen
Class of Stock [Line Items]
Aggregate offering price \| $			$ 200.0			$ 350.0
Commission fee						3.00%

Balance Sheet Account Details (Tables)

6 Months Ended

Jun. 30, 2023

Organization, Consolidation and Presentation of Financial Statements [Abstract]

Schedule of Accounts Receivable


	June 30, 2023		December 31, 2022
Accounts receivable, net:
Accounts receivable, trade	$	7,875,000	$	7,315,000
Allowance for credit losses	(262,000)		(293,000)
	$	7,613,000	$	7,022,000

Schedule of Allowance for Credit Losses

Changes to the allowance for credit losses during the six months ended June 30, 2023 were as follows:


	Allowance for Credit Losses
Balance as of January 1, 2023	$	(293,000)
Provision for expected credit loss	(5,000)
Write-offs and payments	36,000
Balance as of June 30, 2023	$	(262,000)

Schedule of Components of Inventories

The components of inventories are as follows:


	June 30, 2023		December 31, 2022
Inventory:
Raw materials	$	6,204,000	$	5,319,000
Work in process	10,577,000		7,055,000
Finished goods	15,672,000		17,387,000
	$	32,453,000	$	29,761,000

Schedule of Finite-Lived Intangible Assets

Intangible assets that are subject to amortization consisted of the following for the periods presented:


	June 30, 2023						December 31, 2022
	Gross Carrying Amount		Accumulated Amortization		Net Carrying Amount		Gross Carrying Amount		Accumulated Amortization		Net Carrying Amount
Trade name	$	2,630,000	$	(815,000)	$	1,815,000	$	2,630,000	$	(552,000)	$	2,078,000
Customer relationships	4,150,000		(1,587,000)		2,563,000		4,150,000		(1,172,000)		2,978,000
Developed technology	41,600,000		(8,521,000)		33,079,000		41,600,000		(5,615,000)		35,985,000
Intangibles, net	$	48,380,000	$	(10,923,000)	$	37,457,000	$	48,380,000	$	(7,339,000)	$	41,041,000

Schedule of Accrued Liabilities

Accrued expenses consist of the following:


	June 30, 2023		December 31, 2022
Compensation expenses	$	5,917,000	$	7,002,000
Customer deposits	17,000		17,000
Taxes payable	897,000		825,000
Insurance	125,000		613,000
Professional fees and royalties	153,000		210,000
Warranty liabilities	640,000		489,000
Accrued clinical study fees	150,000		250,000
Other	417,000		1,146,000
Total	$	8,316,000	$	10,552,000

Revenue Recognition - Revenue by Source and Geographic Location (Details) - USD ($) $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2023	Jun. 30, 2022	Jun. 30, 2023	Jun. 30, 2022
Disaggregation of Revenue [Line Items]
Revenue	$ 8,662	$ 6,670	$ 16,077	$ 12,366
Americas
Disaggregation of Revenue [Line Items]
Revenue	4,313	2,611	7,757	5,940
EMEA
Disaggregation of Revenue [Line Items]
Revenue	2,748	2,609	5,740	4,348
Asia Pacific
Disaggregation of Revenue [Line Items]
Revenue	$ 1,601	$ 1,450	$ 2,580	$ 2,078
Revenue from Contract with Customer \| Geographic Concentration Risk
Disaggregation of Revenue [Line Items]
Concentration risk percentage	100.00%	100.00%	100.00%	100.00%
Revenue from Contract with Customer \| Geographic Concentration Risk \| Americas
Disaggregation of Revenue [Line Items]
Concentration risk percentage	50.00%	39.00%	48.00%	48.00%
Revenue from Contract with Customer \| Geographic Concentration Risk \| EMEA
Disaggregation of Revenue [Line Items]
Concentration risk percentage	32.00%	39.00%	36.00%	35.00%
Revenue from Contract with Customer \| Geographic Concentration Risk \| Asia Pacific
Disaggregation of Revenue [Line Items]
Concentration risk percentage	18.00%	22.00%	16.00%	17.00%
Product revenue
Disaggregation of Revenue [Line Items]
Revenue	$ 6,609	$ 4,795	$ 12,056	$ 9,001
Instruments
Disaggregation of Revenue [Line Items]
Revenue	2,450	2,446	4,346	4,042
Consumables
Disaggregation of Revenue [Line Items]
Revenue	2,953	1,467	5,188	2,987
Software
Disaggregation of Revenue [Line Items]
Revenue	1,206	882	2,522	1,972
Service and other
Disaggregation of Revenue [Line Items]
Revenue	$ 2,053	$ 1,875	$ 4,021	$ 3,365

Condensed Consolidated Statements of Comprehensive Loss (Unaudited) - USD ($) $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2023	Jun. 30, 2022	Jun. 30, 2023	Jun. 30, 2022
Statement of Comprehensive Income [Abstract]
Net loss:	$ (38,912)	$ (32,158)	$ (76,038)	$ (62,112)
Other comprehensive income (loss):
Unrealized gain (loss) on investment securities	365	(281)	787	(1,379)
Foreign currency translation adjustments	(10)	0	27	0
Other comprehensive income (loss)	355	(281)	814	(1,379)
Total comprehensive loss	$ (38,557)	$ (32,439)	$ (75,224)	$ (63,491)

- Definition

The portion of profit or loss for the period, net of income taxes, which is attributable to the parent.

+ References

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-Section 45
-Paragraph 1B
-Subparagraph (a)
-Publisher FASB
-URI https://asc.fasb.org//1943274/2147482790/220-10-45-1B

Reference 38: http://fasb.org/us-gaap/role/ref/legacyRef
-Topic 220
-SubTopic 10
-Name Accounting Standards Codification
-Section S99
-Paragraph 2
-Subparagraph (SX 210.5-03(20))
-Publisher FASB
-URI https://asc.fasb.org//1943274/2147483621/220-10-S99-2

Reference 39: http://fasb.org/us-gaap/role/ref/legacyRef
-Topic 942
-SubTopic 220
-Name Accounting Standards Codification
-Section S99
-Paragraph 1
-Subparagraph (SX 210.9-04(22))
-Publisher FASB
-URI https://asc.fasb.org//1943274/2147483589/942-220-S99-1

+ Details

Net Loss Per Share (Details) - shares shares in Thousands	6 Months Ended
Net Loss Per Share (Details) - shares shares in Thousands	Jun. 30, 2023	Jun. 30, 2022
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Antidilutive securities excluded from computation of earnings per share amount (in shares)	4,041	3,231
Stock options
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Antidilutive securities excluded from computation of earnings per share amount (in shares)	3,346	2,359
Unvested restricted stock
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Antidilutive securities excluded from computation of earnings per share amount (in shares)	0	384
Warrants
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Antidilutive securities excluded from computation of earnings per share amount (in shares)	436	436
RSUs
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Antidilutive securities excluded from computation of earnings per share amount (in shares)	230	23
PSUs
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Antidilutive securities excluded from computation of earnings per share amount (in shares)	29	29

Cover - shares	6 Months Ended
Cover - shares	Jun. 30, 2023	Aug. 04, 2023
Document Information [Line Items]
Document Type	10-Q
Document Quarterly Report	true
Document Period End Date	Jun. 30, 2023
Document Transition Report	false
Entity File Number	001-38613
Entity Registrant Name	Bionano Genomics, Inc.
Entity Incorporation, State or Country Code	DE
Entity Tax Identification Number	26-1756290
Entity Address, Address Line One	9540 Towne Centre Drive, Suite 100
Entity Address, City or Town	San Diego
Entity Address, State or Province	CA
Entity Address, Postal Zip Code	92121
City Area Code	858
Local Phone Number	888-7600
Entity Current Reporting Status	Yes
Entity Interactive Data Current	Yes
Entity Filer Category	Non-accelerated Filer
Entity Small Business	true
Entity Emerging Growth Company	false
Entity Shell Company	false
Entity Common Stock, Shares Outstanding (in shares)		35,348,440
Amendment Flag	false
Document Fiscal Year Focus	2023
Document Fiscal Period Focus	Q2
Entity Central Index Key	0001411690
Current Fiscal Year End Date	--12-31
Common Stock, $0.0001 par value per share
Document Information [Line Items]
Title of 12(b) Security	Common Stock, $0.0001 par value per share
Trading Symbol	BNGO
Security Exchange Name	NASDAQ
Warrants to purchase Common Stock
Document Information [Line Items]
Title of 12(b) Security	Warrants to purchase Common Stock
Trading Symbol	BNGOW
Security Exchange Name	NASDAQ

Condensed Consolidated Balance Sheets (Parenthetical) - $ / shares	Jun. 30, 2023	Dec. 31, 2022
Statement of Financial Position [Abstract]
Preferred stock, par value (in dollars per share)	$ 0.0001	$ 0.0001
Preferred stock, shares authorized (in shares)	10,000,000	10,000,000
Preferred stock, shares issued (in shares)	0	0
Preferred stock, shares outstanding (in shares)	0	0
Common stock, par value (in dollars per share)	$ 0.0001	$ 0.0001
Common stock, shares authorized (in shares)	400,000,000	400,000,000
Common stock, shares issued (in shares)	33,240,000	29,718,000
Common stock, shares outstanding (in shares)	33,240,000	29,718,000

Balance Sheet Account Details - Narrative (Details) - USD ($) $ in Millions	Jun. 30, 2023	Dec. 31, 2022
Internet Domain Names
Finite-Lived Intangible Assets [Line Items]
Intangible assets not subject to amortization	$ 0.1	$ 0.1

Investments and Fair Value Measurements - Narrative (Details) $ in Thousands	6 Months Ended
	Jun. 30, 2023 USD ($) security	Jun. 30, 2022 USD ($)	Dec. 31, 2022 USD ($) security
Fair Value, Balance Sheet Grouping, Financial Statement Captions [Line Items]
Consideration milestone, change	$ 2,218	$ 158
Number of securities in an unrealized loss position, less than 12 months \| security	15		16
Number of securities in an unrealized loss position, greater than 12 months \| security	11		24
Interest receivable	$ 400		$ 500
Contingent consideration \| BioDiscovery
Fair Value, Balance Sheet Grouping, Financial Statement Captions [Line Items]
Consideration milestone, change	600
Contingent consideration \| Purigen
Fair Value, Balance Sheet Grouping, Financial Statement Captions [Line Items]
Consideration milestone, change	1,600
Consideration milestone payment, maximum	$ 32,000
Contingent consideration \| Measurement Input, Discount Rate
Fair Value, Balance Sheet Grouping, Financial Statement Captions [Line Items]
Measurement input	0.03
Contingent consideration \| Measurement Input, Discount Rate \| Purigen
Fair Value, Balance Sheet Grouping, Financial Statement Captions [Line Items]
Measurement input	0.14
Contingent consideration \| Measurement Input, Probability Factor \| BioDiscovery
Fair Value, Balance Sheet Grouping, Financial Statement Captions [Line Items]
Measurement input	1
Consideration milestone payment	$ 10,000
Contingent consideration \| Measurement Input, Probability Factor \| Purigen \| Minimum
Fair Value, Balance Sheet Grouping, Financial Statement Captions [Line Items]
Measurement input	0.20
Contingent consideration \| Measurement Input, Probability Factor \| Purigen \| Maximum
Fair Value, Balance Sheet Grouping, Financial Statement Captions [Line Items]
Measurement input	0.80

Net Loss Per Share (Tables)

6 Months Ended

Jun. 30, 2023

Earnings Per Share [Abstract]

Schedule of Potentially Dilutive Securities not Included in Calculation of Diluted Net Loss Per Share Attributable to Common Stockholders


	June 30, 2023	June 30, 2022
Stock options	3,346,000	2,359,000
Unvested restricted stock	—	384,000
Warrants	436,000	436,000
RSUs	230,000	23,000
PSUs	29,000	29,000
Total	4,041,000	3,231,000