Bionano Genomics Announces Publication of a New Study Using OGM to Investigate Chromosome Instability during Culture of Induced Pluripotent Stem Cells
iPSCs have the potential to provide greater clinical impact to patients than stem cells while avoiding possible immunological rejection because they can be derived from the patient being treated. In order to be used for gene editing, iPSCs must be created and expanded in culture, opening the possibility for the accrual of chromosomal variants over time. In the study, published in Genes, the authors followed two cell lines over 150 days of continuous culture, or 50 passages, and found significant changes to the genome in both using OGM. Additionally, hundreds of SVs not found in the internal control database were also observed in both cell lines and accumulated over the course of the study, potentially impacting gene expression and cell survival. The authors also suggest that, because of the accumulation of chromosome changes over time and the unknown effects on iPSCs in therapy, culture times should be limited.
“Bionano is expanding into markets where OGM is an alternative workflow for cytogenetics in genetic diseases and cancer. In addition, we are driving adoption of OGM into the academic research community to enable novel discoveries connected to structural variations. This paper outlines the utility of OGM for pharmaceutical research and drug development, which is a segment of the genomics market that Bionano is also targeting,” commented
This publication is available at: https://www.mdpi.com/2073-4425/13/7/1157
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This press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. Words such as “may,” “can” and similar expressions (as well as other words or expressions referencing future events, conditions or circumstances) convey uncertainty of future events or outcomes and are intended to identify these forward-looking statements. Forward-looking statements include statements regarding our intentions, beliefs, projections, outlook, analyses or current expectations concerning, among other things, the potential for SVs to impact iPSCs and the ability for OGM workflows to detect them, and OGM’s potential value in the pharmaceutical research and drug development field. Each of these forward-looking statements involves risks and uncertainties. Actual results or developments may differ materially from those projected or implied in these forward-looking statements. Factors that may cause such a difference include the risks and uncertainties associated with: the adoption of OGM in new fields, including the pharmaceutical research and drug development field, the impact of the COVID-19 pandemic on our business and the global economy; general market conditions; changes in the competitive landscape and the introduction of competitive technologies or improvements to existing technologies; failure of future study results to support those demonstrated in the paper referenced in this press release; changes in our strategic and commercial plans; our ability to obtain sufficient financing to fund our strategic plans and commercialization efforts; the ability of medical and research institutions to obtain funding to support adoption or continued use of our technologies; and the risks and uncertainties associated with our business and financial condition in general, including the risks and uncertainties described in our filings with the
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Source: Bionano Genomics