Bionano Genomics Announces the First Publication Using OGM to Analyze Impact of Chromothripsis and TP53 Abnormalities on Chronic Lymphocytic Leukemia (CLL) Patients with High Genomic Complexity
The paper, published in Cancers journal, was conducted by a multi-center group of researchers from hospitals and academic labs across a number of European countries. The study compared the cytogenomic aberrations observed by genomic microarrays and chromosome banding analysis (CBA) to those observed using OGM. Researchers analyzed a cohort of 162 CLL patients with complex karyotypes, including a subset of 33 CLL patients with cth, to determine whether the presence of cth indicated poor survival outcomes.
In this study, researchers were able to show, for the first time, OGM’s ability to detect cth, and also showed that the OGM results were highly concordant with chromosomal microarray results. The study noted that detecting cth using some traditional cytogenetic approaches can be challenging and reported that OGM was able to reveal rearrangements associated with cth events, including intra-chromosomal and inter-chromosomal translocations. In addition, OGM was able to detect a case with a higher complexity profile, comprising chained translocations involving several chromosomes, which may be characteristic of another event known as chromoplexy.
Though cases with cth showed shorter time to first treatment (TTFT) than non-cth samples, when researchers stratified patients based on TP53 status, cth was no longer associated with TTFT. Only TP53 maintained its significance in the multivariate analysis for TTFT, including cth and genome complexity defined by genomic microarrays, leading the researchers to suggest that TP53 abnormalities, rather than cth itself, underlie the poor prognosis observed in this subset.
“We are excited to see the adoption of OGM in the hematologic community in
This publication can be found here: https://www.mdpi.com/2072-6694/14/15/3715
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This press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. Words such as “believe,” “potential,” and similar expressions (as well as other words or expressions referencing future events, conditions or circumstances) convey uncertainty of future events or outcomes and are intended to identify these forward-looking statements. Forward-looking statements include statements regarding our intentions, beliefs, projections, outlook, analyses or current expectations concerning, among other things, the ability and utility of OGM to analyze chromothripsis (cth) and TP53 abnormalities on chronic lymphocytic leukemia (CLL) patients with high genomic complexity. Each of these forward-looking statements involves risks and uncertainties. Actual results or developments may differ materially from those projected or implied in these forward-looking statements. Factors that may cause such a difference include the risks and uncertainties associated with: the impact of the COVID-19 pandemic on our business and the global economy; general market conditions; changes in the competitive landscape and the introduction of competitive technologies or improvements to existing technologies; failure of OGM to achieve utility in the analysis of chromothripsis (cth) and TP53 abnormalities on chronic lymphocytic leukemia (CLL) patients with high genomic complexity; failure of future study results to support those demonstrated in the paper referenced in this press release; changes in our strategic and commercial plans; our ability to obtain sufficient financing to fund our strategic plans and commercialization efforts; the ability of medical and research institutions to obtain funding to support adoption or continued use of our technologies; and the risks and uncertainties associated with our business and financial condition in general, including the risks and uncertainties described in our filings with the
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Source: Bionano Genomics